Become An Entradan

Research Associate II, Antisense Oligonucleotide

September 25, 2020

Company Overview

Entrada Therapeutics’ mission is to treat devastating diseases through the intracellular delivery of biologics.

Entrada Therapeutics is a biotechnology company dedicated to transforming the treatment of devastating diseases through the intracellular delivery of biologics. Entrada’s technology enables the efficient intracellular delivery of proteins, peptides and nucleic acids, thus allowing for the development of programs across several intracellular target classes. The Company’s novel approach addresses current challenges associated with both large and small molecule therapeutics and represents a fundamental advancement in the delivery of molecules into the cytosol.

Entrada is comprised of experts and leaders in both biologics development and the rare disease space. In December 2018, Entrada closed a $59 million Series A from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital.

Position Summary

Entrada is seeking a highly motivated, collaborative and innovative Research associate specializing in oligonucleotide therapeutics, including but not limited to antisense oligonucleotides and small interfering ribonucleic acids. The candidate will work with a world-class, multidisciplinary team of drug discovery scientists on applying Entrada’s cutting-edge drug delivery platform to develop oligonucleotide-based pipelines for treating some of the most challenging diseases. Specifically, the candidate will work together with scientists to design, prepare and characterize oligonucleotide constructs, and carry out analytical assays for functional validation both in vitro and in vivo. The candidate will contribute to reports and scientific publications as required.

Job Responsibilities

  • Process and analyze samples from in vitro and in vivo studies (e.g. RNA/protein extraction, RT-PCR, RT-qPCR, ELISA, Western blotting, confocal microscopy)
  • Prepare and QC oligonucleotides-peptide conjugates for in vitro and in vivo study
  • Culture and maintain cell lines for in vitro study
  • Develop and execute cell-based assays for validating biological activity of oligonucleotides-peptide conjugates in vitro
  • Prepare SOPs and other reports/documents for assay development and validation
  • Contribute to patents, reports, and publications


Education Requirements

Bachelor or Master in Chemistry, Biochemistry, or related field with 2-year lab experience

Skills and Experiences

  • Hands-on biochemistry experience, such as RT-PCR, qPCR, ELISA, fluorescence microscopy and Western blotting
  • Hands-on experience in oligonucleotides, such as antisense oligonucleotides and siRNAs
  • Hands-on experience in cell culture
  • Ability to collaborate with interdisciplinary team with strong communication skills
  • Desire to work in an innovative and collaborative environment pursuing high reward science
  • Desire to work in an innovative and collaborative environment pursuing high reward science

The Perks

  • Competitive health, dental, and vision coverage
  • Life insurance, short term, long term disability insurance provided
  • Unlimited Vacation
  • 401K
  • Transportation stipend

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

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