Senior / Principal Scientist, Neuromuscular and Cardiac Biology
What’s happening at Entrada Therapeutics? Our mission is simple and direct and that is to treat devastating diseases. Using our proprietary Endosomal Escape Vehicle (EEV) platform, we are advancing a diverse pipeline of oligonucleotide, enzyme, protein, and peptide programs to efficiently engage intracellular targets across multiple therapeutic areas. We’re a tight-knit team of experts and leaders in both therapeutics development and rare disease spaces -- our novel approach to drug design and delivery addresses several important challenges associated with the development of large and small molecule therapeutics, and represents a fundamental advancement in the field of intracellular therapeutics delivery.
With backing from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund, and Agent Capital, Entrada Therapeutics is excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.
The perfect fit:
You are motivated, resourceful, passionate, and looking forward to rolling up your sleeves to develop novel therapies to treat rare skeletal and cardiac diseases. You are excited to play an essential role on our discovery biology team as you’ll have the opportunity to design and execute both in vivo and in vitro experiments to inform our neuromuscular and cardiovascular programs. You should be excited to utilize your strong background in RNA and muscle/cardiac biology to advance our pipeline and collaborate with other teams. You should enjoy working in a fast-paced environment and be seeking a career with growth opportunities, the type of opportunities you only find at a start-up. You should crave collaboration and enjoy being surrounded by a supportive and passionate team who share the same goal of treating devastating diseases.
In this position, you will be part of a larger team, working cross-functionally on discovery-biology, exploring, and developing new therapeutic programs for neuromuscular and cardiovascular disease areas. You will play a critical role in the development, design, and execution of molecular and cellular biology experiments which are critical to the success of our drug discovery programs. You will utilize mouse and cell-based disease models as well as techniques including but not limited to PCR, RNAi, ELISA, EMSA, chromatin immunoprecipitation, Western blot, histological analysis of muscle tissue, cell and tissue culture, and immunostaining techniques (IHC, IF).
At Entrada, our passion for science, our devotion to patients and our values drive our behavior:
Humanity- We genuinely care about patients and about one another
Tenacity- We are relentless and persistent in the pursuit of developing therapies for patients
Creativity- We are creative problem solvers
Collaboration- We are more than the sum of our parts
Curiosity- We have a growth mindset and push conventional thought and theory
To thrive on our team, you will need to come with:
- Your PhD in molecular or cellular biology or a related field with 5+ years of relevant post-graduate experience
- A strong foundational knowledge of muscle and cardiac biology is critical for this role
- Hands-on experience with either animal and/or cell models in skeletal and/or cardiac muscle research is be preferred
- A strong track record of peer-reviewed publications.
- Willingness to explore and develop new therapeutic programs, as well as innovative platforms for target identification
- Capability to work with large data set for meta-analysis is a plus
- Excellent verbal and written communication skills
By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, and you’ll benefit from discretionary time off and an excellent 401K package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.
Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.