Become An Entradan

Senior Scientist, Oligonucleotide Chemistry

November 11, 2020

Company Overview

Entrada Therapeutics is a biotechnology company dedicated to transforming the treatment of devastating diseases through the intracellular delivery of biologics. Entrada’s technology enables the efficient intracellular delivery of oligonucleotide, proteins, and peptides, thus allowing for the development of programs across several intracellular target classes. The Company’s novel approach addresses current challenges associated with both large and small molecule therapeutics and represents a fundamental advancement in the delivery of molecules into the cell. Entrada is comprised of experts and leaders in both biologics development and the rare disease space.

Position Summary

Entrada is seeking a highly motivated, collaborative and innovative Scientist/Sr. Scientist specializing in oligonucleotide chemistry, including but not limited to the design, synthesis, purification, and analysis of oligonucleotides, linkers, and protein/peptide/antibody conjugates. The candidate will work with a world‐class, multidisciplinary team of drug discovery scientists on applying Entrada’s cutting‐ edge drug delivery platform to develop oligonucleotide-based pipelines for treating some of the most challenging diseases. Specifically, the candidate will start the oligonucleotide synthesis at Entrada including establishing the oligo synthesis lab and setting up synthesis, purification, and analytical method protocols. The candidate will mentor junior associates and contribute to the development of drug delivery platform with an interdisciplinary team.

Job Responsibilities

  • Establish oligo synthesis lab to enable milligram to gram scale synthesis andpurification of oligonucleotides
  • Design and optimize oligonucleotide sequences for discovery programs
  • Develop and execute the purification, analytical methods for oligonucleotides and its conjugates with peptide and proteins
  • Manage outsourcing chemistry activities to accelerate internal research activities
  • Prepare SOPs and other reports/documents for assay development and validation
  • Interpret and present research data and findings in internal and external scientific meetings and conferences
  • Contribute effectively to patents, reports, and publications of scientific findings

Skills and Experiences

  • Ph.D. in Organic Chemistry with 3+ years oligonucleotide chemistry experience
  • Demonstrated experience in the synthesis, purification, and characterizations of oligonucleotides
  • Strong understanding and experience with various oligonucleotide chemistries
  • Hands on experience with oligonucleotide synthesizers and purification apparatus
  • Hands on experience with oligo-related analytical techniques
  • Experience in gram-scale multiple step organic synthesis is a plus
  • Experience in oligonucleotide conjugation is a plus
  • Experience in biopharma/biotech is a plus
  • Ability to collaborate with interdisciplinary team with excellent written and oral communication skills
  • Ability to multi‐task to meet research and development goals
  • Drive to solve problems and ability to work independently