Facility Spotlight
Welcome to Entrada
Welcome to the main elevator bank at Entrada! Our Endosomal Escape Vehicle or EEV™ platform is designed to enable the intracellular delivery of therapeutics to disease-causing targets within the cell.
As you enter our office, we want you to get a feel for the cellular entry process. Take a look “under the microscope” to see our EEV-conjugated oligonucleotides in action. Watch as they permeate the cell membrane, representing the first step in our intracellular uptake process.
Endosomal Escape Vehicle
Did you know? ~75% of disease-causing targets are located inside cells and most are still considered inaccessible. At Entrada, we believe we have discovered the solution to this fundamental challenge.
These three panels are an artistic representation of our Endosomal Escape Vehicle or EEV™ platform. Our EEVs bind directly to the phospholipid bilayer causing the EEV-therapeutic to enter the cell through endocytosis. Once inside, the EEV-therapeutic exits the endosome and enters the cell cytosol, where it can reach the intracellular target. Are you intrigued? Visit our Platform page to learn more about how we are working to make intracellular therapeutics a reality.
Puzzle Pieces
Inspired by an illustration in one of our first, and seminal patents, this graphic represents the building blocks (or exons) of mRNA transcripts in people affected by Duchenne muscular dystrophy.
Think about exons like puzzle pieces. When an exon is mutated or missing, the mRNA transcript becomes “out-of-frame” or unreadable by the cell’s machinery. As a result, dystrophin, a protein critical for muscle health, cannot be produced. Our EEV-conjugated oligonucleotides "skip” over an adjacent exon to restore the reading frame. It is our hope that this will allow the body to produce functional dystrophin and maintain muscle health.
