The organization:

What’s happening at Entrada Therapeutics? Our mission is simple and direct and that is to treat devastating diseases. Using our proprietary Endosomal Escape Vehicle (EEV) platform, we are advancing a diverse pipeline of oligonucleotide, enzyme, protein, and peptide programs to efficiently engage intracellular targets across multiple therapeutic areas. We’re a tight-knit team of experts and leaders in both therapeutics development and rare disease spaces -- our novel approach to drug design and delivery addresses several important challenges associated with the development of large and small molecule therapeutics and represents a fundamental advancement in the field of intracellular therapeutics delivery.

With backing from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital, Entrada Therapeutics is excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The perfect fit:

You should be versatile, self-motivated, and looking forward to rolling up your sleeves, as you’ll support aspects of antibody discovery and protein engineering. You’ll support our team more specifically in identifying and testing biologics candidates against therapeutically relevant intracellular targets. You’ll work side-by-side with other team members to help develop innovative medicines for treating some of the most challenging diseases. You’ll have the opportunity to contribute to scientific publications and regulatory submissions.

The opportunity:

In this role you will be a critical contributor to the team, working closely with other scientists and supporting them as you conduct antibody and protein engineering, expression, and purification experiments. Your role will encompass a myriad of work including but not limited to identifying high affinity ligands through high-throughput screening of yeast transformants, screening lead candidates from yeast surface libraries using FACS, and assisting in cell-based assays for target validation. You’ll also be responsible for protein/antibody characterization projects utilizing techniques like SDS-PAGE, western blot, dot blot, etc. Other opportunities would include, presenting data and research findings in internal scientific meetings.

The necessities:

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

Humanity- We genuinely care about patients and about one another

Tenacity- We are relentless and persistent in the pursuit of developing therapies for patients

Creativity- We are creative problem solvers

Collaboration- We are more than the sum of our parts

Curiosity- We have a growth mindset and push conventional thought and theory

To thrive on our team, you will need to come with:

• Your BS/MS in biological science or related field will have you ready to perform at your best as you tackle protein/antibody characterization and purification projects
• A minimum of 1+ years’ wet lab experience from an academic environment, and industry experience certainly doesn’t hurt
• Hands-on experience with cell culture, gene cloning, SDS-PAGE, and western blots is critical and additional experience with flow cytometry (FACS) is a plus
• Experience with antibody engineering and display techniques like yeast display is highly valuable, but we are happy to teach these
• Excellent working knowledge and familiarity of DNA analysis software as well as Microsoft Office will have you making major contributions in no time

The perks:

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, and you’ll benefit from discretionary time off and an excellent 401K package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

The organization:

What’s happening at Entrada Therapeutics? Our mission is simple and direct and that is to treat devastating diseases. Using our proprietary Endosomal Escape Vehicle (EEV) platform, we are advancing a diverse pipeline of oligonucleotide, enzyme, protein and peptide programs to efficiently engage intracellular targets across multiple therapeutic areas. We’re a tight-knit team of experts and leaders in both therapeutics development and rare disease spaces -- our novel approach to drug design and delivery addresses several important challenges associated with the development of large and small molecule therapeutics, and represents a fundamental advancement in the field of intracellular therapeutics delivery.

With backing from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital, Entrada Therapeutics is excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The perfect fit:

You should be a versatile, self-motivated, and looking forward to rolling up your sleeves, as you’ll be involved in all aspects of oligonucleotides, supporting efforts for antisense oligonucleotides, small interfering ribonucleic acids and gene editing platforms. You should be ready to support our team of drug discovery scientists as we design, prepare and characterize oligonucleotide constructs and carry out analytical assays for functional validation both in vitro and in vivo.

The opportunity:

In this role you will have the opportunity to be involved in a lot of different aspects of our oligonucleotide work, for example processing and analyzing samples from in vitro and in vivo studies will be just one of your areas of work. You’ll be expected to work through techniques like RNA/protein extraction, RT-PCR, RT-qPCR, ELISA, and western blot. You’ll also have the opportunity to maintain and culture cell lines for in vitro studies, as well as developing and executing cell-based assays for validating biological activity of oligonucleotide therapeutics. Lastly, you’ll have the opportunity to prepare SOPs and other reports and publications.

The necessities:

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

Humanity- We genuinely care about patients and about one another

Tenacity- We are relentless and persistent in the pursuit of developing therapies for patients

Creativity- We are creative problem solvers

Collaboration- We are more than the sum of our parts

Curiosity- We have a growth mindset and push conventional thought and theory

To thrive on our team, you will need to come with:

• At least 2+ years’ experience in a lab, and industry experience certainly doesn’t hurt.
• Your BS/MS in molecular biology, pharmacology, biochemistry or similar field will have you ready to perform at your best with us as you come with hands-on biochemistry experience with techniques like RT-PCR, qPCR, ELISA, fluorescence microscopy, cell culture and western blot
• We’re really hoping you have hands on experience with oligonucleotides and CRISPR editing
• To be effective on our team, we need you to bring excellent working knowledge and familiarity of graphic software and Microsoft Office.

The perks:

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, and you’ll benefit from discretionary time off and an excellent 401K package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

The organization:

What’s happening at Entrada Therapeutics? Our mission is simple and direct and that is to treat devastating diseases. Using our proprietary Endosomal Escape Vehicle (EEV) platform, we are advancing a diverse pipeline of oligonucleotide, enzyme, protein and peptide programs to efficiently engage intracellular targets across multiple therapeutic areas. We’re a tight-knit team of experts and leaders in both therapeutics development and rare disease spaces -- our novel approach to drug design and delivery addresses several important challenges associated with the development of large and small molecule therapeutics, and represents a fundamental advancement in the field of intracellular therapeutics delivery.

With backing from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital, Entrada Therapeutics is excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The perfect fit:

You should be a self-motivated and highly collaborative research associate looking forward to rolling up your sleeves, as you’ll be involved in aspects of our oligonucleotide chemistry group. Your background should be in chemistry, with a significant amount experience with synthesis and analysis of oligonucleotides. You’ll work side-by-side with others in your group to help develop innovative medicines for treating some of the most challenging diseases.

The opportunity:

In this role you will be responsible for the operation and routine maintenance of multiple instruments like HPLC, LCMS, and our oligonucleotide synthesizer. You will have the opportunity to utilize this equipment for purification, characterization and purity determination of prepared compounds and developing analytical methods and purification methods of oligonucleotides. There will be other more standard components to the role like managing chemical inventory, ordering chemical and supplies, as well as preparing procedures and other reports. There will also be other stretch opportunities like presenting data and research findings at internal meetings.

The necessities:

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

Humanity- We genuinely care about patients and about one another

Tenacity- We are relentless and persistent in the pursuit of developing therapies for patients

Creativity- We are creative problem solvers

Collaboration- We are more than the sum of our parts

Curiosity- We have a growth mindset and push conventional thought and theory

To thrive on our team, you will need to come with:

• Your BS/MS in organic chemistry or similar will have you ready to perform at your best with us as you come with experience in organic synthesis, oligonucleotide chemistry, analytical chemistry of oligonucleotides and hands on experience with oligonucleotide synthesizers
• We hope you have experience with chromatography techniques LC-MS, ion exchange and RP-HPLC but by no means is this mandatory
• Have you worked in an industry setting before? Great, but again isn’t a must have, we just hope you are able to multi-task well to meet our research and development goals
• You should thrive in a fast-paced environment and interact effectively with multiple disciplinaries
• Don’t forget about the opportunity to present internally, you should be an excellent communicator, both written and verbally

The perks:

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, and you’ll benefit from discretionary time off and an excellent 401K package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

The organization:

What’s happening at Entrada Therapeutics? Our mission is simple and direct and that is to treat devastating diseases. Using our proprietary Endosomal Escape Vehicle (EEV) platform, we are advancing a diverse pipeline of oligonucleotide, enzyme, protein and peptide programs to efficiently engage intracellular targets across multiple therapeutic areas. We’re a tight-knit team of experts and leaders in both therapeutics development and rare disease spaces -- our novel approach to drug design and delivery addresses several important challenges associated with the development of large and small molecule therapeutics, and represents a fundamental advancement in the field of intracellular therapeutics delivery.

With backing from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital, Entrada Therapeutics is excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The perfect fit:

You are a motivated, resourceful, and enthusiastic biologics-focused Analytical Development Senior Scientist excited to support the company at a critical stage in its growth trajectory. You excel at developing, qualifying, and implementing analytical methods using state-of-the-art instrumentation, including but not limited to HPLC/UPLC, LC-MS, LC-MS/MS, CE and iCE. If you can perform these activities with minimal supervision, yet thrive in a collaborative setting, this role is for you. At Entrada, you will not be siloed, but rather expected to interact across different functional groups, including Discovery, Process Development, Pharmacology, Product Development, and CRO/CMOs. Your ability and desire to thrive in a nimble, fast-paced results-driven environment will set you up for success.

The opportunity:

In this position you will own the analytical developmental needs for the identity, purity, and safety analysis of a variety of different therapeutic modalities, including biologics (antibodies and antibody modalities), peptides, glycans, oligonucleotides and conjugates thereof. This work will support early discovery, process development, and product characterization activities for the evaluation of drug substance, drug product, and stability samples. Ideally, you will be able to perform these analytical method development, optimization, and qualification projects under minimal supervision while leaning on internal and external experts when needed. Furthermore, you will review and evaluate new methodologies/techniques to add to or improve laboratory capabilities and efficiencies. You will be responsible for maintaining laboratory equipment by following appropriate calibration and maintenance activities. You will be a mentor with the potential to manage scientist and research associates in the future. Finally, we hope you enjoy communicating your processes and findings across different formats including authoring and reviewing standard test methods, reports, protocol writing, regulatory filings (IND, IMPD, etc.), patent applications, publications (including review for technical correctness and regulatory compliance) and in internal and external meetings because your work will be critical to the success of the entire company and our ability to treat devastating diseases.

The necessities:

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

Humanity- We genuinely care about patients and about one another

Tenacity- We are relentless and persistent in the pursuit of developing therapies for patients

Creativity- We are creative problem solvers

Collaboration- We are more than the sum of our parts

Curiosity- We have a growth mindset and push conventional thought and theory

To thrive on our team, you will need to come with:

• A Ph.Din Biochemistry, Analytical Chemistry, Molecular Biology or a related discipline with 4-7 years of relevant post-graduate biologics method development experience in the Biotech or Pharmaceutical industries (post-graduate academic experience will be considered)
• A strong background in the areas of analytical chemistry/biochemistry, with emphasis on experience and in-depth working knowledge of HPLC/UPLC， LC-MS， LC-MS/MS，CE， iCE and SDS-PAGE is essential
• Specific experience with biologics (therapeutic antibodies, recombinant proteins, etc.) is required, while additional experience with Oligonucleotides is valuable
• Experience with purity (RP-HPLC, SEC-HPLC, AEX/CEX-HPLC), identity (LC-MS high resolution intact mass), aggregates (SEC-HPLC, SEC-MALS), charge variants (AEX/CEX/CIEF/iCIEF), sequencing (LC-MS/MS) techniques is ideal
• Working knowledge of phase appropriate regulatory requirements applicable to analytical development and testing is highly desirable
• Method development experience for both early- and late-stage programs is highly desirable
• Excellent communication (written and verbal) and interpersonal skills
• Works independently with minimal supervision and is highly collaborative with other groups
• Results driven in line with project and team objectives
• Ability to handle multiple high priority tasks in parallel to meet organizational goals

The perks:

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, and you’ll benefit from discretionary time off and an excellent 401K package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

Accounting Manager

The organization:

What’s happening at Entrada Therapeutics? Our mission is simple and direct and that is to treat devastating diseases. Using our proprietary Endosomal Escape Vehicle (EEV) platform, we are advancing a diverse pipeline of oligonucleotide, enzyme, protein and peptide programs to efficiently engage intracellular targets across multiple therapeutic areas. We’re a tight-knit team of experts and leaders in both therapeutics development and rare disease spaces -- our novel approach to drug design and delivery addresses several important challenges associated with the development of large and small molecule therapeutics, and represents a fundamental advancement in the field of intracellular therapeutics delivery.

With backing from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital, Entrada Therapeutics is excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The perfect fit:

You should be versatile, self-motivated, and looking forward to rolling up your sleeves, as you will manage all aspects of accounting and financial reporting. You will support and learn from our corporate controller, and will help set the company up for timely and accurate financial results through the implementation of new systems and processes. You thrive in a nimble, fast paced environment, and are driven by results.

The opportunity:

Reporting to the Controller, the accounting manager must be anenthusiastic builder with a solid technical accounting background. This position will havefront-line general ledger management responsibilities with cross-departmentcollaboration opportunities and visibility to management.

• Build and manage the accounting function and the monthly closing process.
• Own the general ledger chart of accounts and future project coding.
• Assist with the preparation of internal and external financial reporting.
• Lead contact for external auditors. Responsibilities include providing deliverables, reviewing technical memos, preparing the financial statements.
• Review (and prepare when needed) journal entries and balance sheet reconciliations.
• Lead effort and execute implementation of new enterprise resource planning system (ERP).
• Work with Controller to implement a control framework that will satisfy SOX404.
• Assist when needed for budgeting, forecasting, and long-range planning

The necessities:

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

Humanity- We genuinely care about patients and about one another

Tenacity- We are relentless and persistent in the pursuit of developing therapies for patients

Creativity- We are creative problem solvers

Collaboration- We are more than the sum of our parts

Curiosity- We have a growth mindset and push conventional thought and theory

To thrive on our team, you will need to come with:

• Your BS/MS in finance/accounting and at least 5+ years accounting experience, preferable with the Big 4.
• CPA is strongly preferred.
• Experience within the Life science industry.
• Exposure to SEC reporting is required
• To be effective on our team, we need you to bring excellent working knowledge of complex accounting issues and technical accounting research experience.
• You should be a strong communicator and have excellent organization skills -- this will be super important as the company grows

The perks:

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, and you’ll benefit from discretionary time off and an excellent 401K package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

Senior Analyst, Accounting and Operations

The organization:

What’s happening at Entrada Therapeutics? Our mission is simple and direct and that is to treat devastating diseases. Using our proprietary Endosomal Escape Vehicle (EEV) platform, we are advancing a diverse pipeline of oligonucleotide, enzyme, protein and peptide programs to efficiently engage intracellular targets across multiple therapeutic areas. We’re a tight-knit team of experts and leaders in both therapeutics development and rare disease spaces -- our novel approach to drug design and delivery addresses several important challenges associated with the development of large and small molecule therapeutics, and represents a fundamental advancement in the field of intracellular therapeutics delivery.

With backing from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital, Entrada Therapeutics is excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The perfect fit:

You should be versatile, self-motivated, and looking forward to rolling up your sleeves, as you’ll be involved in several aspects of accounting and financial operations. You will support and learn from our corporate controller, overseeing accounts payable, payroll and areas of financial reporting. You should enjoy working in a fast-paced environment and be seeking career growth opportunities, the type of opportunities you only find at a start-up. You should be an excellent communicator and enjoy working with a collaborative team.

The opportunity:

Manage the account payable function with the help of our third-party procurement team

• Ensure accurate data entry of all vendor invoices
• Resolve purchase order, invoice, or payment discrepancies
• Verify vendor accounts by reconciling monthly statements and related transactions
• Maintain and improve systems, procedures, and policies around the procure-to-pay function

Responsible for bi-weekly payroll

• Input US payroll twice a month, ensuring new hire information, terminations, and all other changes are accurately reflected
• Prepare payroll-related journal entries
• Respond to employee questions in a timely manner
• Coordinate with HR on benefits to ensure accuracy of information used in payroll
• Prepare for year-end W-2s by assisting with entering commuter taxable entries and other fringe benefits
• Review the accuracy of W-2s and prepare reconciliations for employees
• Coordinate with various auditors on required support for audits

Be a key part of the accounting team

• Perform monthly close activities including balance sheet reconciliations
• Prepare and enter month-end journal entries
• Contribute ideas to improve process, procedure, and system efficiency
• Participate in quarterly reviews and annual audits
• Other duties and special projects as we continue to grow

The necessities:

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

Humanity- We genuinely care about patients and about one another

Tenacity- We are relentless and persistent in the pursuit of developing therapies for patients

Creativity- We are creative problem solvers

Collaboration- We are more than the sum of our parts

Curiosity- We have a growth mindset and push conventional thought and theory

To thrive on our team, you will need to come with:

• BS/BA degree (Accounting or Finance preferred) and 2-5 years of experience in an Accounting role (biotech experience preferred)
• Excellent Excel skills required

• Working knowledge or desire to learn our various financial systems (ADP Run, Prendio, Bill.com, and Quickbooks)
• Able to work in a fast-paced, deadline-oriented environment
• Outstanding communications skills (written, verbal and presentation)

The perks:

By becoming a team member here at Entrada, you will have access to excellent health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance and you’ll benefit from a discretionary time off package and flexible work arrangements. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

Principal Scientist, Bioinformatics

The organization:

What’s happening at Entrada Therapeutics? Our mission is simple and direct and that is to treat devastating diseases. Using our proprietary Endosomal Escape Vehicle (EEV) platform, we are advancing a diverse pipeline of oligonucleotide, enzyme, protein and peptide programs to efficiently engage intracellular targets across multiple therapeutic areas. We’re a tight-knit team of experts and leaders in both therapeutics development and rare disease spaces -- our novel approach to drug design and delivery addresses several important challenges associated with the development of large and small molecule therapeutics, and represents a fundamental advancement in the field of intracellular therapeutics delivery.

With backing from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital, Entrada Therapeutics is excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The perfect fit:

You should be versatile, self-motivated, and looking forward to rolling up your sleeves, as you’ll be involved in all types of data integration and analysis. You should be excited to play a critical role in the development of a bioinformatics and computational platform for oligonucleotide therapeutics discovery. You should enjoy working in a fast-paced environment and collaborating seamlessly across functions with excellent verbal and written skills.

The opportunity:

In this role you will play a critical role in the development of a bioinformatics and computational platform for oligonucleotide therapeutics discovery. You will contribute to the overall scientific strategy for oligonucleotide therapeutics, with a focus on sequence design, data analysis and integration. You should be excited to share your findings across the research teams and serve as the technical and scientific lead.

The necessities:

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

Humanity- We genuinely care about patients and about one another

Tenacity- We are relentless and persistent in the pursuit of developing therapies for patients

Creativity- We are creative problem solvers

Collaboration- We are more than the sum of our parts

Curiosity- We have a growth mindset and push conventional thought and theory

To thrive on our team, you will need to come with:

• Your PhD in bioinformatics, information sciences, cheminformatics, computational chemistry or a related field will have you ready to perform at your best with at least 6+ years of industry experience in the field of oligonucleotide therapeutics
• You should be an expert in solving scientific problems using program language (python/Perl)
• Your experience using bioinformatics platforms to analyze RNA alternative splicing, RNA secondary structure and pathway analysis should have you ready to succeed in this position
• You should be familiar in therapeutic modalities targeting RNAs (antisense oligo, siRNA, miRNA, gene therapy)
• Having experience in building machine learning/artificial intelligence models based on oligonucleotide data is a great plus, but not a must have for the role
• Would be great if you’ve had experience processing, organizing, analyzing and visualizing complex data and information, such as high throughput genomics and genetics data

The perks:

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, and you’ll benefit from discretionary time off and an excellent 401K package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

The organization:

What’s happening at Entrada Therapeutics? Our mission is simple and direct and that is to treat devastating diseases. Using our proprietary Endosomal Escape Vehicle (EEV) platform, we are advancing a diverse pipeline of oligonucleotide, enzyme, protein, and peptide programs to efficiently engage intracellular targets across multiple therapeutic areas. We’re a tight-knit team of experts and leaders in both therapeutics development and rare disease spaces -- our novel approach to drug design and delivery addresses several important challenges associated with the development of large and small molecule therapeutics, and represents a fundamental advancement in the field of intracellular therapeutics delivery.

With backing from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund, and Agent Capital, Entrada Therapeutics is excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The perfect fit:

If you are persistent, detail-orientated, self-motivated, and looking forward to rolling up your sleeves to drive cutting edge antibody engineering and discovery, we are looking for you! You should be excited to play an essential role in the development of our pipeline as you’ll have the opportunity to design and create antibody therapeutics specific to novel intracellular targets utilizing our proprietary drug delivery platform. You should enjoy working in a fast-paced environment and be seeking a career with growth opportunities, the type of opportunities you only find at a start-up. You should crave collaboration and enjoy being surrounded by a supportive and passionate team who share the same goal of treating devastating diseases.

The opportunity:

In this position, you will own your antibody discovery and development projects while leaning on internal and external experts when needed. You will play a critical role in the development, design, and execution of antibody library screenings, utilizing yeast display methods and flow cytometry (FACS) to characterize novel biotherapeutic lead candidates. You’ll leverage both rational and random protein engineering methods to optimize candidate leads for improved stability, CMC, and pharmacological properties. We expect our Scientists to share their ideas and we listen! Finally, we hope you enjoy communicating your processes and findings across different formats including protocol writing, regulatory filings, patent applications, publications and in internal and external meetings because people will want to know what you’ve discovered.

The necessities:

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

Humanity- We genuinely care about patients and about one another

Tenacity- We are relentless and persistent in the pursuit of developing therapies for patients

Creativity- We are creative problem solvers

Collaboration- We are more than the sum of our parts

Curiosity- We have a growth mindset and push conventional thought and theory

To thrive on our team, you will need to come with:

• Your PhD in molecular biology, structural biology, protein biochemistry, cell biology, or a related field with a strong foundational knowledge of molecular biology techniques
• Expertise in therapeutic antibody lead identification including library creation and screening techniques is a must – a huge bonus if you have experience developing antibodies against intracellular therapeutic targets.
• Knowledge and hands-on experience utilizing phage and yeast display techniques coupled with FACs are critical
• Experience in antibody optimization, single domain antibody formats, and engineering including antibody humanization, CDR grafting, biophysical properties optimization, and protein structural modeling would be valuable
• Experience with biophysical characterization of biotherapeutics using techniques such as SPR, Octet and DSC and the ability to partner with our in vitro and in vivo POC teams is a bonus
• Familiarity with chemical coupling, peptide conjugation, and antibody drug conjugates would be valuable
• A strong desire to join forces with your colleagues, thrive in a collaborative environment, and communicate across wide audiences will allow you to hit the ground running
• Excellent verbal and written communication skills

The perks:

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, and you’ll benefit from discretionary time off and an excellent 401K package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

The organization:

What’s happening at Entrada Therapeutics? Our mission is simple and direct and that is to treat devastating diseases. Using our proprietary Endosomal Escape Vehicle (EEV) platform, we are advancing a diverse pipeline of oligonucleotide, enzyme, protein and peptide programs to efficiently engage intracellular targets across multiple therapeutic areas. We’re a tight-knit team of experts and leaders in both therapeutics development and rare disease spaces -- our novel approach to drug design and delivery addresses several important challenges associated with the development of large and small molecule therapeutics, and represents a fundamental advancement in the field of intracellular therapeutics delivery.

With backing from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital, Entrada Therapeutics is excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The perfect fit:

You are a motivated, resourceful, and enthusiastic individual Business Strategy & Analytics Associate excited to support the company at a critical stage in its growth trajectory. You will add value and learn from the Head of Business Development and Operations, supporting the development of a comprehensive pipeline and business development strategy, market analytics and competitive intelligence function. You will partner with the leadership and R&D team to balance data and insights with sound instincts and strong judgement. You thrive in a nimble, fast paced environment and are driven by results.

The opportunity:

Support corporate strategic planning initiatives, crafting strategic frameworks, and conducting analysis of market intelligence and data to drive recommendations

• Work with cross-functional teams to support new strategies for therapeutic areas, target product profiles and development plans for individual candidate medicines
• Support KOL identification and discussions to gather primary insights
• Support market / eNPV modeling for individual assets and indications
• Synthesize media, database, analyst reports, R&D days, and earnings calls to keep track of all the diseases and targets relevant to the Entrada portfolio
• Work with the strategy and research teams to develop impact related assessments on Entrada’s programs, platform and investment strategy

Evaluate potential partners’ capabilities and needs, and drive appropriate financial analysis to enable evaluation of opportunities

• Work with Head of Business Development to assess financial implications of strategic investments; both internal and via academic and commercial partnerships
• Support engagement of potential partners and deal modeling

The necessities:

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

Humanity- We genuinely care about patients and about one another

Tenacity- We are relentless and persistent in the pursuit of developing therapies for patients

Creativity- We are creative problem solvers

Collaboration- We are more than the sum of our parts

Curiosity- We have a growth mindset and push conventional thought and theory

To thrive on our team, you will need to come with:

• Life sciences undergraduate degree (biology, biochemistry, chemistry, etc.), or in relevant analytical disciplines including engineering, math or finance strongly preferred
• 1-2 years of relevant experience, preferably in management consulting, investment banking, venture capital, or at a biotech or pharmaceutical company
• Experience in strategic evaluations and market / technology due diligence
• Strong analytical skills and broad business understanding of the life sciences business and R&D process; knowledge of financial modeling
• Outstanding communications skills (written, verbal and presentation)

The perks:

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, and you’ll benefit from discretionary time off and an excellent 401K package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

Scientist/Senior Scientist, Oligonucleotide Chemistry

The organization:

What’s happening at Entrada Therapeutics? Our mission is simple and direct and that is to treat devastating diseases. Using our proprietary Endosomal Escape Vehicle (EEV) platform, we are advancing a diverse pipeline of oligonucleotide, enzyme, protein and peptide programs to efficiently engage intracellular targets across multiple therapeutic areas. We’re a tight-knit team of experts and leaders in both therapeutics development and rare disease spaces -- our novel approach to drug design and delivery addresses several important challenges associated with the development of large and small molecule therapeutics, and represents a fundamental advancement in the field of intracellular therapeutics delivery.

With backing from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital, Entrada Therapeutics is excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The perfect fit:

You should be a self-motivated scientist ooking forward to working at a brand newstate-of-the art synthesis and purification lab. You should love the synthesis, purification and characterizations of oligonucleotides. You will collaborate closely with the Principal Scientist at the company to develop oligonucleotide-based pipelines for treating some of the most challenging diseases. If you’re looking for an environment to roll up your sleeves and play a direct role in advancing validated targets into the drug discovery pipeline, this could be the right opportunity for you!

The opportunity:

In this role you will be responsible for helping to establishthe company’s oligo synthesis lab, contributing to the synthesis of oligonucleotides and their conjugates from milligram to grams. In doing so you will also have the opportunity to contribute to establishing the purification and analysis methods for your group. Along with these responsibilities, you should be excited to interpret and present your research findings at scientific meetings and conferences. You should be excited to utilize these scientific findings to contribute to the patents, reports and publications.

The necessities:

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

Humanity- We genuinely care about patients and about one another

Tenacity- We are relentless and persistent in the pursuit of developing therapies for patients

Creativity- We are creative problem solvers

Collaboration- We are more than the sum of our parts

Curiosity- We have a growth mindset and push conventional thought and theory

To thrive on our team, you will need to come with:

• At least 3years of experience with oligonucleotide chemistry and working within industry would be a huge plus!
• Your PhD in organic chemistry or a related field should have you ready to perform oligonucleotide chemistry (synthesis, purification, and analysis)
• You should be a naturally collaborative and a strong communicator, and let’s not forget the ability to multi-task effectively would be a huge plus in this fast paced environment

The perks:

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, and you’ll benefit from discretionary time off and an excellent 401K package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

Research Associate, in vitro Pharmacology

The organization:

What’s happening at Entrada Therapeutics? Our mission is simple and direct and that is to treat devastating diseases. Using our proprietary Endosomal Escape Vehicle (EEV) platform, we are advancing a diverse pipeline of oligonucleotide, enzyme, protein and peptide programs to efficiently engage intracellular targets across multiple therapeutic areas. We’re a tight-knit team of experts and leaders in both therapeutics development and rare disease spaces -- our novel approach to drug design and delivery addresses several important challenges associated with the development of large and small molecule therapeutics, and represents a fundamental advancement in the field of intracellular therapeutics delivery.

With backing from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital, Entrada Therapeutics is excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The perfect fit:

You should be versatile, self-motivated, and looking forward to rolling up your sleeves, as you’ll be involved in all aspects of molecular cellular pharmacology, leading efforts for developing cell-based assays for candidate optimization, drug candidate validation and overseeing in vitro pharmacology studies for preclinical proof-of-concept. You’ll support our intracellular oligonucleotide and biologics discovery and development efforts and will team up with the Discovery Group and other functions to move programs from target identification to preclinical proof-of-concept. You’ll work side-by-side with Scientists performing experiments and research and will provide biology insights on new targets as part of the Pharmacology Group, giving you the opportunity to play a direct role in advancing validated targets into the drug discovery pipeline.

The opportunity:

In this role you will be responsible for the integrity and quality of internal in vitro data package while designing, conducting, and managing in vitro biologically relevant cellular assays to evaluate mechanistic and physiologically relevant functional activity data package. Utilizing internal and external resources to execute pharmacology studies and preclinical translational studies relevant for rare neuromuscular and immunology related disease, your partners in the Discovery Group with work with you to generate mechanistic proof-of-concept and contribute to selecting novel therapeutic modalities that includes antibody, peptides, and oligonucleotides. You’ll independently design molecular or cellular assays aligned with the targeted disease mechanism and represent the group by presenting data and research findings in the weekly pharmacology and cross functional discovery/antibody meetings.

The necessities:

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

Humanity- We genuinely care about patients and about one another

Tenacity- We are relentless and persistent in the pursuit of developing therapies for patients

Creativity- We are creative problem solvers

Collaboration- We are more than the sum of our parts

Curiosity- We have a growth mindset and push conventional thought and theory

To thrive on our team, you will need to come with:

• At least 2+ years’ experience from an academic environment, and industry experience certainly doesn’t hurt.
• Your BS/MS will have you ready to perform at your best with us as you come with experience in state-of-the-art in vitro laboratory techniques (PCR, DNA and protein gel electrophoresis, Western blots, RNA preps, quantitative real-time PCR, mammalian cell line tissue culture).
• We hope you have exposure to mammalian transfection and lentiviral related experience, but it’s not mandatory, although an ability to solve problems while designing and performing experiments is!
• We want to hear about the original thinking and deductive reasoning you’ve used to solve routine operation and scientific problems.
• To be effective on our team, we need you to bring excellent working knowledge and familiarity of graphic software and Microsoft Office.

The perks:

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, and you’ll benefit from discretionary time off and an excellent 401K package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

Company Overview

Entrada Therapeutics is a biotechnology company dedicated to transforming the treatment of devastating diseases through the intracellular delivery of macromolecules including oligonucleotides and biologics. Entrada’s technology enables the efficient intracellular delivery of proteins, peptides and nucleic acids, thus allowing for the development of programs across several intracellular target classes. The Company’s novel approach addresses current challenges associated with both large and small molecule therapeutics and represents a fundamental advancement in the intracellular delivery of therapeutics.

Entrada is comprised of experts and leaders in both drug development and the rare disease space. In December 2018, Entrada closed a $59 million Series A from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital.

Position Summary

Entrada is hiring a highly motivated, collaborative and innovative Drug Metabolism and Pharmacokinetics (DMPK) expert to lead our preclinical DMPK activities in support of the Company’s intracellular oligonucleotide and biologics discovery and development efforts. The successful candidate will report to the Head of Product Development and work with a world-class, multidisciplinary team of drug development scientists and lead the design, analysis and interpretation of preclinical in vitro and in vivo studies. Specifically, the candidate will design, manage and execute in vitro and in vivo programs both in-house and at contract research organizations. The candidate will also be responsible for analyzing, interpreting and modeling DMPK and PK/PD studies. The successful candidate will also have exceptional verbal and written communication skills and will be expected to contribute to scientific publications and regulatory submissions as required.

Job Responsibilities

• Lead all aspects of DMPK design, manage and execute in vitro/in vivo experiments to support preclinical characterization of drug candidates
• Develop and coordinate the execution of studies for measuring drug concentration, target engagement and pharmacodynamic effects in vitro and in vivo
• Lead and coordinate outsourced preclinical studies by interacting closely with CROs
• Partner with the discovery team, toxicology and clinical managers to optimize preclinical models and lead candidates to inform first-in-patient clinical dosing strategies
• Author study reports to support IND filings
• Champion innovation and new initiatives for discovery programs by proactively reviewing literature and other advancements in disease area biology
• Interpret and present research data and findings in internal and external scientific meetings and conferences
• Contribute effectively to patents and scientific publications

Qualifications

Required

• Ph.D. in pharmacology or a relevant scientific discipline
• 6+ years of relevant industrial or academic experience in pharmacokinetics and pharmacology
• Demonstrated knowledge of ADME, PK/PD, toxicokinetics and bioanalytical development of protein therapeutics/biologics/oligonucelotides
• Deep understanding of translational biology
• Significant experience in bioanalytical techniques including assays for assessing serum/tissue drug levels and immunogenicity
• Experience in pre-clinical PK-PD modeling
• Experience with writing technical study reports and supporting IND submissions
• Ability to collaborate in an interdisciplinary team setting spanning discovery to clinical operations and strategy with excellent written and oral communication skills
• Ability to manage multiple high priority activities to support research and company development goals
• Excellent analytical reasoning skills and the ability to effectively troubleshoot and perform root cause analyses

Preferred

• Understanding of in vitro and in vivo toxicology assessment and histopathology
• Experience in assay development for target engagement and biomarker discovery
• Understanding of clinical trial design and PK modeling to support first-in-human clinical studies