Position Summary

Entrada is seeking a highly motivated, proactive, collaborative, and innovative scientist with a background in bioorganic chemistry to join Entrada’s discovery efforts. The candidate will work with a world-class, multidisciplinary team of drug discovery scientists on applying cutting-edge peptide and oligonucleotide chemistry to develop leads for compelling biological targets. Specifically, the candidate will design and execute medicinal chemistry studies and use proprietary display technology to develop next-generation constrained peptidomimetics. The candidate will contribute to scientific publications and regulatory submissions as required.

Job Responsibilities

• Design and execute the synthesis, purification, and characterizations of peptides and oligonucleotides development candidates
• Design and execute the synthesis and characterizations of peptide and oligonucleotide library for SAR studies
• Work with other team members to implement assays for ascertaining target engagement, validating biological activity in vitro (e.g. alphascreen, TR-FRET, fluorescence polarization, cell-based functional assay)
• Manage, organize, and critically evaluate data independently.
• Champion innovation and new initiatives in discovery programs by proactively reviewing literature and other advancements
• Interpret and present research data and findings in internal and external scientific meetings and conferences
• Contribute effectively to patents, reports, and publications of scientific findings

Education Requirements

• Ph.D. in organic chemistry, chemical biology, medicinal chemistry, bioorganic chemistry, or a relevant scientific discipline

Skills and Experiences

• Demonstrated experience in the design, synthesis, and purification of peptides and oligonucleotides
• Skilled with solid-phase peptide synthesizers, method optimization and conjugations
• Demonstrated experience with HPLC, LC-MS systems and other analytical instruments
• Hands-on experience with oligonucleotide synthesizers is a plus
• Hands-on experience with flow-based solid phase synthesis is a plus
• Experience with hit optimization, SAR study, target engagement and other medicinal chemistry principals is a plus
• Ability to collaborate with interdisciplinary team with excellent written and oral communication skills
• Ability to learn fast, grasp the “essence”, and multi-task to meet research and development goals
• Drive to solve problems and ability to work independently

Company Overview

Entrada Therapeutics is a biotechnology company dedicated to transforming the treatment of devastating diseases through the intracellular delivery of biologics. Entrada’s technology enables the efficient intracellular delivery of proteins, peptides and nucleic acids, thus allowing for the development of programs across several intracellular target classes. The Company’s novel approach addresses current challenges associated with both large and small molecule therapeutics and represents a fundamental advancement in the delivery of molecules into the cytosol.

Entrada is comprised of experts and leaders in both biologics development and the rare disease space. In December 2018, Entrada closed a $59 million Series A from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital.

Position Summary

We currently have an exciting opportunity available to join the Fermentation group at Entrada Therapeutics. We are seeking a highly motivated, collaborative, and innovative Sr. Research Associate with a background in fermentation/cell culture. The candidate will be responsible for the designing and execution of small- and medium-scale microbial (E. coli, Pichia pastoris) fermentations to support the discovery and development of Entrada’s biologics pipeline. The candidate will work with a world-class, multidisciplinary team of drug discovery and development scientists to evaluate new clinical candidates and develop new processes. Specifically, the candidate will focus on the improvements of fermentation and high throughput screening workflow to produce recombinant therapeutic proteins using microbial expression systems. The candidate will also contribute to scientific publications and regulatory submissions as required.

Job Responsibilities

• Plan the fermentation and primary recovery experiments according to objective priority by interacting with various departments within Entrada
• Independently designs and troubleshoots fermentation and primary recovery experiments
• Set-up, inoculate, and operate meticulously shake flasks, small- and medium-scale yeast and bacterial fermentations
• Perform primary recovery such as cell harvest, homogenization, inclusion body wash, solubilization, and refolding
• Run SDS-PAGE gels, HPLC to monitor metabolite levels and protein expression
• Record experimental details and observations in the laboratory notebooks
• Present data and research findings in internal team meetings

Qualifications

• Ph.D./MS/BS in Biochemical Engineering, Biotechnology, Biochemistry or related fields
• Ph.D. or MS with 2+ years or BS with 4+ years of experience related to fermentation process development of recombinant proteins
• Experience working with E. coli, Pichia pastoris for expression of recombinant proteins
• Experience with primary recovery operations such as centrifugation, homogenization, solubilization, refolding (a plus)
• Knowledge and use of molecular biology and biochemistry techniques
• Strong understanding of bioreactor design and transport phenomena as it relates to bioprocess scale-up and applied control theory
• Desire to work in an innovative and collaborative environment pursuing high reward science

Company Overview

Entrada Therapeutics is a biotechnology company dedicated to transforming the treatment of devastating diseases through the intracellular delivery of biologics. Entrada’s technology enables the efficient intracellular delivery of proteins, peptides and nucleic acids, thus allowing for the development of programs across several intracellular target classes. The Company’s novel approach addresses current challenges associated with both large and small molecule therapeutics and represents a fundamental advancement in the delivery of molecules into the cytosol.

Entrada is comprised of experts and leaders in both biologics development and the rare disease space. In December 2018, Entrada closed a $59 million Series A from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital.

Position Summary

Entrada is hiring an executive Office Administrator. This is a diverse role in which the candidate will support existing administrative functions and can apply innovation and design to implement new systems for improvements. The ideal candidate is an individual that will demonstrate dynamic and forward thinking and act as a constructive resource for our team. The successful candidate must be a self-starter, with the ability to work in a fast paced, scientific environment. This position requires an individual that is highly organized, with a strong communicative and interpersonal skill set.

Job Responsibilities

• Oversee and support all administrative duties in the office and ensure that office is operating smoothly
• Maintain and organize general office supply inventory and purchases
• Manage and maintain IT infrastructure: create, and update tickets, meet with technicians, facilitate external platform integrations, maintain hardware inventory, review SOPs, ensure compliance
• Develop office policies and procedures, and ensure they are implemented appropriately
• Facilitate pre-onboarding and initial employee onboarding process; including interview scheduling, 1:1 setup, IT equipment coordination, following the official onboarding process; own the process of guiding a new hire from pre-arrival through their first week
• Maintain and improve internal operations and procedures
• Assist in the training of staff on numerous administrative items, including scheduling the onboarding of new platforms for our team
• Independently perform improvement projects which require a combination of administrative, creative, and communications skills
• Manage front-line external relationships, licensee, facilities, internet, etc.
• Support scientific operations through research and evaluation of vendors, initiate conversations, prepare summaries and pitch to leadership teams
• Communicate and facilitate interrelated efforts from administration to lab to executive team
• Maintain working knowledge of company policies, shared documents and folders
• Organize, prepare, and dispatch documents to executive team
• Willingness to contribute to internal company ‘culture’; promote our ever-growing idea of team culture
• Contribute to and develop external facing cultural presence, LinkedIn, Twitter, Facebook page
• Provide other administrative support as necessary, including scheduling meetings, maintaining calendars, resolving administrative issues
• Preparation and management of mailing and shipments to/from office
• Perform receptionist duties: check in and greet visitors
• Arrange corporate travel for team members (as needed)
• Coordinate company lunches
• Assist with company event planning

Qualifications

• BA/BS Degree preferred
• At least 2 years of work experience in an executive assistant/office management role
• Previous experience in the biotechnology industry preferred
• Proficient with Microsoft Office
• Extensive knowledge of PowerPoint features; design and formatting
• Strong communication skills (oral and written) and ability to work effectively across functions
• Strong organizational and time management skills
• Demonstrates consistent attention to detail
• Advanced comfort with technology; familiar with IT troubleshooting and navigation
• Desire to work in an innovative and collaborative environment pursuing high reward science

Company Overview

Entrada Therapeutics is a biotechnology company dedicated to transforming the treatment of devastating diseases through the intracellular delivery of biologics. Entrada’s technology enables the efficient intracellular delivery of proteins, peptides and nucleic acids, thus allowing for the development of programs across several intracellular target classes. The Company’s novel approach addresses current challenges associated with both large and small molecule therapeutics and represents a fundamental advancement in the delivery of molecules into the cytosol.

Entrada is comprised of experts and leaders in both biologics development and the rare disease space. In December 2018, Entrada closed a $59 million Series A from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital.

Position Summary

Entrada is hiring for a Pharmacology/In Vivo Biology Senior Scientist to drive the Company’s intracellular biologics discovery programs. This individual will work closely with the Discovery Group and other functions to progress programs from target identification to preclinical proof-of-concept. The successful candidate is expected to be involved in all aspects of translational science, leading efforts for developing cell-based assays for candidate optimization, drug candidate validation and overseeing pharmacology studies for PK/PD and preclinical proof-of-concept.

The successful candidate will also provide biology insights on new targets and therapeutic hypotheses to guide drug discovery efforts and translation into the clinic. This individual is expected to directly lead from the bench and work with research associates and CROs to perform experiments and biological research. As part of the Biology Group, the Biology Senior Scientist has the opportunity to contribute broadly in advancing validated targets into the drug discovery pipeline. Title will be commensurate with experience.

Job Responsibilities

• Investigate and validate novel biology of interested targets
• Collaborate with Discovery Group to generate mechanistic proof-of-concept and contribute to selecting novel therapeutic modalities that include antibody, peptides and oligonucleotides
• Experience in PD biomarker identification and development for intracellular/extracellular targets
• Design, conduct and manage in vitro and in vivo experiments to evaluate mechanistic, , ADME and PK profiles of developmental candidates
• Experience in oligo nucleotide mediated delivery for neuromuscular targets
• Utilize internal and external resources to execute pharmacology studies and preclinical translational studies relevant for neurological disorders
• Engage key opinion leaders and collaborators to drive program to clinical development
• Mentor junior members of Discovery Biology Group
• Present data and research findings in internal team meetings, review meetings and external conferences

Qualifications

• Ph.D. or equivalent in neuromuscular biology or relevant field with strong publication record
• More than 5 years of industry experience preferably in rare genetic diseases
• Demonstrated understanding of in vitro and in vivo mechanistic and functional studies using oligonucleotide mediated delivery
• Experience working with multiple mammalian cell culture systems, including cell lines ,and primary cell cultures
• Hands-on experience in technologies including ELISA, immunohistochemistry, immunofluorescence, in-situ hybridization, western blotting, flow cytometry and qPCR
• Proven ability to work independently, solve problems and initiate new ideas
• Strong communication skill and ability to work effectively across functions
• “Hands-on” mentality in moving projects forward
• Desire to work in an innovative and collaborative environment pursuing high reward science

Company Overview

Entrada Therapeutics is a biotechnology company dedicated to transforming the treatment of devastating diseases through the intracellular delivery of biologics. Entrada’s technology enables the efficient intracellular delivery of proteins, peptides and nucleic acids, thus allowing for the development of programs across several intracellular target classes. The Company’s novel approach addresses current challenges associated with both large and small molecule therapeutics and represents a fundamental advancement in the delivery of molecules into the cytosol.

Entrada is comprised of experts and leaders in both biologics development and the rare disease space. In December 2018, Entrada closed a $59 million Series A from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital.

Position Summary

Entrada is hiring for a highly motivated, collaborative and innovative Principal Scientist, specializing in pharmacokinetics and pharmacology to join the Company’s intracellular biologics discovery and development efforts.

The candidate will work with a world-class, multidisciplinary team of drug discovery scientists and lead the in vitro and in vivo ADME, PK, PD and toxicokinetic efforts. Specifically, the candidate will design, manage and execute in vitro and in vivo programs both inhouse and at contract research organizations. The candidate will also be responsible for analyzing, interpreting and modeling DMPK and PK/PD data. The candidate will contribute to scientific publications and regulatory submissions as required.

Job Responsibilities

• Design, manage and execute in vitro, and in vivo experiments to evaluate the ADME and PK profiles as well as toxicokinetics and immunogenicity of developmental intracellular biologics candidates both in-house and at contract research organizations
• Develop and execute assays for measuring drug concentration, target engagement and pharmacodynamic effects in vitro and in vivo
• Champion innovation and new initiatives for discovery programs by proactively reviewing literature and other advancements in disease area biology
• Interpret and present research data and findings in internal and external scientific meetings and conferences
• Contribute effectively to patents, reports and publications of scientific findings

Qualifications

• Ph.D. in pharmaceutics, pharmacology or a relevant scientific discipline • A minimum of 8 years’ experience in pharmacokinetics and pharmacology
• Demonstrated knowledge of ADME, PK/PD and bioanalytical development of protein therapeutics/biologics
• Deep understanding of translational biology
• Experience in bioanalytical techniques including assays for immunogenicity, in vitro and in vivo toxicology and histopathology preferred
• Experience in assay development for target engagement and biomarker discovery preferred Experience in contributing DMPK and pharmacology sections of regulatory submissions preferred
• Ability to collaborate in an interdisciplinary team setting with excellent written and oral communication skills
• Ability to multi-task to meet research and development goals
• Drive to solve problems and ability to work independently Compensation is competitive and commensurate with experience.