The organization:

What’s happening at Entrada Therapeutics? Our mission is simple and direct and that is to treat devastating diseases. Using our proprietary Endosomal Escape Vehicle (EEV) platform, we are advancing a diverse pipeline of oligonucleotide, enzyme, protein, and peptide programs to efficiently engage intracellular targets across multiple therapeutic areas. We’re a tight-knit team of experts and leaders in both therapeutics development and rare disease spaces -- our novel approach to drug design and delivery addresses several important challenges associated with the development of large and small molecule therapeutics, and represents a fundamental advancement in the field of intracellular therapeutics delivery.

With backing from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund, and Agent Capital, Entrada Therapeutics is excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The perfect fit:

You should be versatile, self-motivated, and looking forward to rolling up your sleeves, as you will be involved in all aspects of neuromuscular and cardiac biology. Your team player mentality and excellent communication skills will allow you to collaborate effectively as you work alongside your team as well as cross-functionally.

The opportunity:

In this position, you will be part of a cross-functional team exploring new therapeutic programs for neuromuscular and cardiovascular disease areas. You will play a critical role in the development and execution of molecular and cellular biology experiments which are critical to the success of our drug discovery programs. You will utilize cell-based disease models, and techniques such as PCR, Western blot, cell and tissue culture, and immunostaining (IHC, IF).

The necessities:

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

Humanity- We genuinely care about patients and about one another

Tenacity- We are relentless and persistent in the pursuit of developing therapies for patients

Creativity- We are creative problem solvers

Collaboration- We are more than the sum of our parts

Curiosity- We have a growth mindset and push conventional thought and theory

To thrive on our team, you will need to come with:

• Your B.S./M.S. in Molecular/Cellular biology or a related field with 2+ years of relevant academic or industry experience will have you ready to perform on our team
• It is highly desirable that you come with hands-on experience with in vitro models of skeletal/cardiac muscle
• We would love for you to have a foundational knowledge of skeletal/cardiac muscle biology, but by no means is it required!
• You should have excellent verbal and written communication skills– you will have a lot of opportunities to demonstrate this every day!

The perks:

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, and you’ll benefit from discretionary time off and an excellent 401K package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

The organization:

What’s happening at Entrada Therapeutics? Our mission is simple and direct and that is to treat devastating diseases. Using our proprietary Endosomal Escape Vehicle (EEV) platform, we are advancing a diverse pipeline of oligonucleotide, enzyme, protein and peptide programs to efficiently engage intracellular targets across multiple therapeutic areas. We’re a tight-knit team of experts and leaders in both therapeutics development and rare disease spaces -- our novel approach to drug design and delivery addresses several important challenges associated with the development of large and small molecule therapeutics, and represents a fundamental advancement in the field of intracellular therapeutics delivery.

With backing from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital, Entrada Therapeutics is excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The perfect fit:

You should be a self-motivated and highly collaborative leader looking forward to rolling up your sleeves, as you’ll be involved in leading all aspects of our oligonucleotide chemistry group. Your background should be in chemistry, with a significant amount experience with oligonucleotide drug discovery and development. You’ll work side-by-side with your cross function leads to help develop this platform for treating some of the most challenging diseases.

The opportunity:

In this role you will be responsible for managing process development and manufacturing supply logistics of oligonucleotides and conjugates (API) for preclinical and clinical development, including timelines, budgets, risks & mitigations plans for process development, starting materials, and non-GMP and GMP manufacturing campaigns. You will have the opportunity to actively manage development activities at CDMOs for project-specific activities. You’ll also have the opportunity to review technical reports and to draft CMC sections of regulatory submissions. You should be excited to act as the technical subject matter expert (SME) internally for troubleshooting process chemistry issues. As a leader, you should be excited to have the opportunity to recruit, supervise, mentor and guide direct reports to build a high-performance collaborative culture and to facilitate their scientific and career growth.

The necessities:

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

Humanity- We genuinely care about patients and about one another

Tenacity- We are relentless and persistent in the pursuit of developing therapies for patients

Creativity- We are creative problem solvers

Collaboration- We are more than the sum of our parts

Curiosity- We have a growth mindset and push conventional thought and theory

To thrive on our team, you will need to come with:

• Your PhD in Chemistry or relevant discipline will have you ready to perform at your best with us as you come with 10 years of experience in an industry setting, preferably in oligonucleotide process development OR your MS in Organic Chemistry or relevant discipline with 15 years of experience in industry and preferably in oligonucleotide process development
• You should have thorough knowledge of process chemistry and scale-up to develop and implement robust and efficient oligonucleotide drug substance manufacturing processes across the development continuum
• Make sure to share with us your knowledge of regulatory and quality too!
• We hope you have experience in technology transfers (managing or executing), and analytical techniques like HPLC, UPLC, NMR, KF, UV, LC-MS, we’d also love for you to have experience working with CDMOs
• You should have experience leading a team in chemistry, if you haven’t that’s ok just be ready to share with us experiences that would translate well
• You should have excellent communication, organizational and presentation skills, you’ll have a lot of opportunities to demonstrate this everyday!

The perks:

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, and you’ll benefit from discretionary time off and an excellent 401K package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

The organization:

What’s happening at Entrada Therapeutics? Our mission is simple and direct and that is to treat devastating diseases. Using our proprietary Endosomal Escape Vehicle (EEV) platform, we are advancing a diverse pipeline of oligonucleotide, enzyme, protein and peptide programs to efficiently engage intracellular targets across multiple therapeutic areas. We’re a tight-knit team of experts and leaders in both therapeutics development and rare disease spaces -- our novel approach to drug design and delivery addresses several important challenges associated with the development of large and small molecule therapeutics, and represents a fundamental advancement in the field of intracellular therapeutics delivery.

With backing from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital, Entrada Therapeutics is excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The perfect fit:

You are a motivated, resourceful, and enthusiastic biologics-focused Analytical Development Senior Scientist excited to support the company at a critical stage in its growth trajectory. You excel at developing, qualifying, and implementing analytical methods using state-of-the-art instrumentation, including but not limited to HPLC/UPLC, LC-MS, LC-MS/MS, CE and iCE. If you can perform these activities with minimal supervision, yet thrive in a collaborative setting, this role is for you. At Entrada, you will not be siloed, but rather expected to interact across different functional groups, including Discovery, Process Development, Pharmacology, Product Development, and CRO/CMOs. Your ability and desire to thrive in a nimble, fast-paced results-driven environment will set you up for success.

The opportunity:

In this position you will own the analytical developmental needs for the identity, purity, and safety analysis of a variety of different therapeutic modalities, including biologics (antibodies and antibody modalities), peptides, glycans, oligonucleotides and conjugates thereof. This work will support early discovery, process development, and product characterization activities for the evaluation of drug substance, drug product, and stability samples. Ideally, you will be able to perform these analytical method development, optimization, and qualification projects under minimal supervision while leaning on internal and external experts when needed. Furthermore, you will review and evaluate new methodologies/techniques to add to or improve laboratory capabilities and efficiencies. You will be responsible for maintaining laboratory equipment by following appropriate calibration and maintenance activities. You will be a mentor with the potential to manage scientist and research associates in the future. Finally, we hope you enjoy communicating your processes and findings across different formats including authoring and reviewing standard test methods, reports, protocol writing, regulatory filings (IND, IMPD, etc.), patent applications, publications (including review for technical correctness and regulatory compliance) and in internal and external meetings because your work will be critical to the success of the entire company and our ability to treat devastating diseases.

The necessities:

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

Humanity- We genuinely care about patients and about one another

Tenacity- We are relentless and persistent in the pursuit of developing therapies for patients

Creativity- We are creative problem solvers

Collaboration- We are more than the sum of our parts

Curiosity- We have a growth mindset and push conventional thought and theory

To thrive on our team, you will need to come with:

• A Ph.Din Biochemistry, Analytical Chemistry, Molecular Biology or a related discipline with 4-7 years of relevant post-graduate biologics method development experience in the Biotech or Pharmaceutical industries (post-graduate academic experience will be considered)
• A strong background in the areas of analytical chemistry/biochemistry, with emphasis on experience and in-depth working knowledge of HPLC/UPLC， LC-MS， LC-MS/MS，CE， iCE and SDS-PAGE is essential
• Specific experience with biologics (therapeutic antibodies, recombinant proteins, etc.) is required, while additional experience with Oligonucleotides is valuable
• Experience with purity (RP-HPLC, SEC-HPLC, AEX/CEX-HPLC), identity (LC-MS high resolution intact mass), aggregates (SEC-HPLC, SEC-MALS), charge variants (AEX/CEX/CIEF/iCIEF), sequencing (LC-MS/MS) techniques is ideal
• Working knowledge of phase appropriate regulatory requirements applicable to analytical development and testing is highly desirable
• Method development experience for both early- and late-stage programs is highly desirable
• Excellent communication (written and verbal) and interpersonal skills
• Works independently with minimal supervision and is highly collaborative with other groups
• Results driven in line with project and team objectives
• Ability to handle multiple high priority tasks in parallel to meet organizational goals

The perks:

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, and you’ll benefit from discretionary time off and an excellent 401K package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

The organization:

What’s happening at Entrada Therapeutics? Our mission is simple and direct and that is to treat devastating diseases. Using our proprietary Endosomal Escape Vehicle (EEV) platform, we are advancing a diverse pipeline of oligonucleotide, enzyme, protein and peptide programs to efficiently engage intracellular targets across multiple therapeutic areas. We’re a tight-knit team of experts and leaders in both therapeutics development and rare disease spaces -- our novel approach to drug design and delivery addresses several important challenges associated with the development of large and small molecule therapeutics, and represents a fundamental advancement in the field of intracellular therapeutics delivery.

With backing from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital, Entrada Therapeutics is excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The perfect fit:

You should be a self-motivated, highly collaborative, and innovative bioorganic chemist looking forward to rolling up your sleeves as you’ll be designing and executing medicinal chemistry studies to develop next-generation intracellular biologics. You’ll collaborate with the team to apply cutting-edge peptide and oligonucleotide chemistry to develop leads for compelling biological targets. You’ll also have the opportunity to contribute to scientific publications when possible.

The opportunity:

In this role you will be responsible for designing and executing peptide and peptidomimetic optimization studies with both combinatorial chemistry, medicinal chemistry, and in silico techniques. You will have the opportunity to develop and execute assays for ascertaining target engagement and for validating biological activity in vitro through techniques like alphascreen, TR-FRET, fluorescence polarization, and cell-based functional assays. Along with these responsibilities, you should be excited to interpret and present your research findings at scientific meetings and conferences. You should be excited to utilize these scientific findings to contribute to the patents, reports, and publications.

The necessities:

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

Humanity- We genuinely care about patients and about one another

Tenacity- We are relentless and persistent in the pursuit of developing therapies for patients

Creativity- We are creative problem solvers

Collaboration- We are more than the sum of our parts

Curiosity- We have a growth mindset and push conventional thought and theory

To thrive on our team, you will need to come with:

• Your PhD in bioorganic chemistry, medicinal chemistry, chemical biology, or related field will have you ready to perform at your best as you come with experience with U/HPLC, MS, and other analytical instruments for compound characterization and purification
• You should have experience with hit optimization, SAR studies, target engagement, and other medicinal chemistry strategies
• We’d love for you to have experience with in vitro pharmacology or computational chemistry packages like Glide or Autodock, but by no means is it mandatory
• You should be a naturally collaborative and a strong communicator, and let’s not forget the ability to multi-task effectively would be a huge plus in this fast-paced environment
• You should have excellent communication, organizational, and presentation skills- you’ll have a lot of opportunities to demonstrate this every day!

​​​​​​​

The perks:

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, and you’ll benefit from discretionary time off and an excellent 401K package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

The organization:

What’s happening at Entrada Therapeutics? Our mission is simple and direct and that is to treat devastating diseases. Using our proprietary Endosomal Escape Vehicle (EEV) platform, we are advancing a diverse pipeline of oligonucleotide, enzyme, protein and peptide programs to efficiently engage intracellular targets across multiple therapeutic areas. We’re a tight-knit team of experts and leaders in both therapeutics development and rare disease spaces -- our novel approach to drug design and delivery addresses several important challenges associated with the development of large and small molecule therapeutics, and represents a fundamental advancement in the field of intracellular therapeutics delivery.

With backing from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital, Entrada Therapeutics is excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The perfect fit:

You should be versatile, self-motivated, and looking forward to rolling up your sleeves, as you’ll be involved in all aspects of molecular cellular pharmacology, leading efforts for developing cell-based assays for candidate optimization, drug candidate validation and overseeing in vitro pharmacology studies for preclinical proof-of-concept. You’ll support our intracellular oligonucleotide and biologics discovery and development efforts and will team up with the Discovery Group and other functions to move programs from target identification to preclinical proof-of-concept. You’ll work side-by-side with Scientists performing experiments and research and will provide biology insights on new targets as part of the Pharmacology Group, giving you the opportunity to play a direct role in advancing validated targets into the drug discovery pipeline.

The opportunity:

In this role you will be responsible for the integrity and quality of internal in vitro data package while designing, conducting, and managing in vitro biologically relevant cellular assays to evaluate mechanistic and physiologically relevant functional activity data package. Utilizing internal and external resources to execute pharmacology studies and preclinical translational studies relevant for rare neuromuscular and immunology related disease, your partners in the Discovery Group with work with you to generate mechanistic proof-of-concept and contribute to selecting novel therapeutic modalities that includes antibody, peptides, and oligonucleotides. You’ll independently design molecular or cellular assays aligned with the targeted disease mechanism and represent the group by presenting data and research findings in the weekly pharmacology and cross functional discovery/antibody meetings.

The necessities:

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

Humanity- We genuinely care about patients and about one another

Tenacity- We are relentless and persistent in the pursuit of developing therapies for patients

Creativity- We are creative problem solvers

Collaboration- We are more than the sum of our parts

Curiosity- We have a growth mindset and push conventional thought and theory

To thrive on our team, you will need to come with:

• At least 2+ years’ experience from an academic environment, and industry experience certainly doesn’t hurt.
• Your BS/MS will have you ready to perform at your best with us as you come with experience in state-of-the-art in vitro laboratory techniques (PCR, DNA and protein gel electrophoresis, Western blots, RNA preps, quantitative real-time PCR, mammalian cell line tissue culture).
• We hope you have exposure to mammalian transfection and lentiviral related experience, but it’s not mandatory, although an ability to solve problems while designing and performing experiments is!
• We want to hear about the original thinking and deductive reasoning you’ve used to solve routine operation and scientific problems.
• To be effective on our team, we need you to bring excellent working knowledge and familiarity of graphic software and Microsoft Office.

The perks:

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, and you’ll benefit from discretionary time off and an excellent 401K package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

Executive Assistant to CEO

The organization:

What’s happening at Entrada Therapeutics? Our mission is simple and direct and that is to treat devastating diseases. Using our proprietary Endosomal Escape Vehicle (EEV) platform, we are advancing a diverse pipeline of oligonucleotide, enzyme, protein and peptide programs to efficiently engage intracellular targets across multiple therapeutic areas. We’re a tight-knit team of experts and leaders in both therapeutics development and rare disease spaces -- our novel approach to drug design and delivery addresses several important challenges associated with the development of large and small molecule therapeutics, and represents a fundamental advancement in the field of intracellular therapeutics delivery.

With backing from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital, Entrada Therapeutics is excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The perfect fit:

You operate independently, live in the details and able to anticipate the team’s needs, while seamlessly pivoting to meet changing priorities in a fast-paced environment. You follow up and follow through, connecting problems with solutions with efficiency. You work successfully in a team environment with strong interpersonal skills to effectively build working relationships inside and outside the company.

The opportunity:

The Executive Assistant will provide a variable scale of administrative support to the Entrada team, primarily focused on high-level support to the CEO and c-suiteResponsibilities may include:

• Provides seamless administrative support for C-Suite.
• Coordinate Board of Directors meetings and weekly executive team meetings.
• Execute on a wide range of operational tasks – frequent and complex calendar scheduling, direct communication with board of directors and external stakeholders, management, drafting of correspondence (sometimes of a confidential nature), and more.

• Draft, design, and edit corporate files as needed, including external & internal presentations and meeting materials.
• Prioritize conflicting needs and proactively follow up, often under tight deadlines.

• Document management: Assist in filing, tracking, and delivery of board books.
• Support the maintenance of both electronic and physical filing systems legal documents, Board of Director records, and special projects.
• Post COVID-19 Travel: Coordinate and track domestic and international travel arrangements for executive management team.
• Assist with special projects as needed.
• Maintain employees’ confidence and protect operations by keeping company proprietary information confidential.

The necessities:

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

Humanity- We genuinely care about patients and about one another

Tenacity- We are relentless and persistent in the pursuit of developing therapies for patients

Creativity- We are creative problem solvers

Collaboration- We are more than the sum of our parts

Curiosity- We have a growth mindset and push conventional thought and theory

To thrive on our team, you will need to come with:

• 6-10 years of administrative experience with proven track record of experience in a fast-paced, dynamic environment
• Bachelor’s Degree Required
• Excellent communication and problem-solving skills

• Highly flexible team player with demonstrated professional maturity to readily prioritize and anticipate needs

• Responsive and proactive with the ability to work well under tight deadlines and respond to rapidly changing demands
• Strong organizational and analytical skills that reflect ability to perform and prioritize multiple tasks seamlessly with excellent attention to detail
• Ability to work with minimal supervision and maintain a high standard of confidentiality

• Highly proficient technical skills including Microsoft Office Suite (Word, Outlook, Excel, PowerPoint, SharePoint, etc.)
• Start-up and/or biotech experience is strongly preferred

The perks:

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, and you’ll benefit from discretionary time off and an excellent 401K package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

The organization:

What’s happening at Entrada Therapeutics? Our mission is simple and direct and that is to treat devastating diseases. Using our proprietary Endosomal Escape Vehicle (EEV) platform, we are advancing a diverse pipeline of oligonucleotide, enzyme, protein, and peptide programs to efficiently engage intracellular targets across multiple therapeutic areas. We’re a tight-knit team of experts and leaders in both therapeutics development and rare disease spaces -- our novel approach to drug design and delivery addresses several important challenges associated with the development of large and small molecule therapeutics, and represents a fundamental advancement in the field of intracellular therapeutics delivery.

With backing from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund, and Agent Capital, Entrada Therapeutics is excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The perfect fit:

You are motivated, resourceful, passionate, and looking forward to rolling up your sleeves to develop novel therapies to treat rare skeletal and cardiac diseases. You are excited to play an essential role on our discovery biology team as you’ll have the opportunity to design and execute both in vivo and in vitro experiments to inform our neuromuscular and cardiovascular programs. You should be excited to utilize your strong background in RNA and muscle/cardiac biology to advance our pipeline and collaborate with other teams. You should enjoy working in a fast-paced environment and be seeking a career with growth opportunities, the type of opportunities you only find at a start-up. You should crave collaboration and enjoy being surrounded by a supportive and passionate team who share the same goal of treating devastating diseases.

The opportunity:

In this position, you will be part of a larger team, working cross-functionally on discovery-biology, exploring, and developing new therapeutic programs for neuromuscular and cardiovascular disease areas. You will play a critical role in the development, design, and execution of molecular and cellular biology experiments which are critical to the success of our drug discovery programs. You will utilize mouse and cell-based disease models as well as techniques including but not limited to PCR, RNAi, ELISA, EMSA, chromatin immunoprecipitation, Western blot, histological analysis of muscle tissue, cell and tissue culture, and immunostaining techniques (IHC, IF).

The necessities:

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

Humanity- We genuinely care about patients and about one another

Tenacity- We are relentless and persistent in the pursuit of developing therapies for patients

Creativity- We are creative problem solvers

Collaboration- We are more than the sum of our parts

Curiosity- We have a growth mindset and push conventional thought and theory

To thrive on our team, you will need to come with:

• Your PhD in molecular or cellular biology or a related field with 5+ years of relevant post-graduate experience
• A strong foundational knowledge of muscle and cardiac biology is critical for this role
• Hands-on experience with either animal and/or cell models in skeletal and/or cardiac muscle research is be preferred
• A strong track record of peer-reviewed publications.
• Willingness to explore and develop new therapeutic programs, as well as innovative platforms for target identification
• Capability to work with large data set for meta-analysis is a plus
• Excellent verbal and written communication skills

The perks:

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, and you’ll benefit from discretionary time off and an excellent 401K package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

The organization:

What’s happening at Entrada Therapeutics? Our mission is simple and direct and that is to treat devastating diseases. Using our proprietary Endosomal Escape Vehicle (EEV) platform, we are advancing a diverse pipeline of oligonucleotide, enzyme, protein, and peptide programs to efficiently engage intracellular targets across multiple therapeutic areas. We’re a tight-knit team of experts and leaders in both therapeutics development and rare disease spaces -- our novel approach to drug design and delivery addresses several important challenges associated with the development of large and small molecule therapeutics and represents a fundamental advancement in the field of intracellular therapeutics delivery.

With backing from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital, Entrada Therapeutics is excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The perfect fit:

You should be versatile, self-motivated, and looking forward to rolling up your sleeves, as you’ll support aspects of antibody discovery and protein engineering. You’ll support our team more specifically in identifying and testing biologics candidates against therapeutically relevant intracellular targets. You’ll work side-by-side with other team members to help develop innovative medicines for treating some of the most challenging diseases. You’ll have the opportunity to contribute to scientific publications and regulatory submissions.

The opportunity:

In this role you will be a critical contributor to the team, working closely with other scientists and supporting them as you conduct antibody and protein engineering, expression, and purification experiments. Your role will encompass a myriad of work including but not limited to identifying high affinity ligands through high-throughput screening of yeast transformants, screening lead candidates from yeast surface libraries using FACS, and assisting in cell-based assays for target validation. You’ll also be responsible for protein/antibody characterization projects utilizing techniques like SDS-PAGE, western blot, dot blot, etc. Other opportunities would include, presenting data and research findings in internal scientific meetings.

The necessities:

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

Humanity- We genuinely care about patients and about one another

Tenacity- We are relentless and persistent in the pursuit of developing therapies for patients

Creativity- We are creative problem solvers

Collaboration- We are more than the sum of our parts

Curiosity- We have a growth mindset and push conventional thought and theory

To thrive on our team, you will need to come with:

• Your BS/MS in biological science or related field will have you ready to perform at your best as you tackle protein/antibody characterization and purification projects
• A minimum of 1+ years’ wet lab experience from an academic environment, and industry experience certainly doesn’t hurt
• Hands-on experience with cell culture, gene cloning, SDS-PAGE, and western blots is critical and additional experience with flow cytometry (FACS) is a plus
• Experience with antibody engineering and display techniques like yeast display is highly valuable, but we are happy to teach these
• Excellent working knowledge and familiarity of DNA analysis software as well as Microsoft Office will have you making major contributions in no time

The perks:

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, and you’ll benefit from discretionary time off and an excellent 401K package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

The organization:

What’s happening at Entrada Therapeutics? Our mission is simple and direct and that is to treat devastating diseases. Using our proprietary Endosomal Escape Vehicle (EEV) platform, we are advancing a diverse pipeline of oligonucleotide, enzyme, protein and peptide programs to efficiently engage intracellular targets across multiple therapeutic areas. We’re a tight-knit team of experts and leaders in both therapeutics development and rare disease spaces -- our novel approach to drug design and delivery addresses several important challenges associated with the development of large and small molecule therapeutics, and represents a fundamental advancement in the field of intracellular therapeutics delivery.

With backing from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital, Entrada Therapeutics is excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The perfect fit:

You should be a versatile, self-motivated, and looking forward to rolling up your sleeves, as you’ll be involved in all aspects of oligonucleotides, supporting efforts for antisense oligonucleotides, small interfering ribonucleic acids and gene editing platforms. You should be ready to support our team of drug discovery scientists as we design, prepare and characterize oligonucleotide constructs and carry out analytical assays for functional validation both in vitro and in vivo.

The opportunity:

In this role you will have the opportunity to be involved in a lot of different aspects of our oligonucleotide work, for example processing and analyzing samples from in vitro and in vivo studies will be just one of your areas of work. You’ll be expected to work through techniques like RNA/protein extraction, RT-PCR, RT-qPCR, ELISA, and western blot. You’ll also have the opportunity to maintain and culture cell lines for in vitro studies, as well as developing and executing cell-based assays for validating biological activity of oligonucleotide therapeutics. Lastly, you’ll have the opportunity to prepare SOPs and other reports and publications.

The necessities:

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

Humanity- We genuinely care about patients and about one another

Tenacity- We are relentless and persistent in the pursuit of developing therapies for patients

Creativity- We are creative problem solvers

Collaboration- We are more than the sum of our parts

Curiosity- We have a growth mindset and push conventional thought and theory

To thrive on our team, you will need to come with:

• At least 2+ years’ experience in a lab, and industry experience certainly doesn’t hurt.
• Your BS/MS in molecular biology, pharmacology, biochemistry or similar field will have you ready to perform at your best with us as you come with hands-on biochemistry experience with techniques like RT-PCR, qPCR, ELISA, fluorescence microscopy, cell culture and western blot
• We’re really hoping you have hands on experience with oligonucleotides and CRISPR editing
• To be effective on our team, we need you to bring excellent working knowledge and familiarity of graphic software and Microsoft Office.

The perks:

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, and you’ll benefit from discretionary time off and an excellent 401K package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

The organization:

What’s happening at Entrada Therapeutics? Our mission is simple and direct and that is to treat devastating diseases. Using our proprietary Endosomal Escape Vehicle (EEV) platform, we are advancing a diverse pipeline of oligonucleotide, enzyme, protein and peptide programs to efficiently engage intracellular targets across multiple therapeutic areas. We’re a tight-knit team of experts and leaders in both therapeutics development and rare disease spaces -- our novel approach to drug design and delivery addresses several important challenges associated with the development of large and small molecule therapeutics, and represents a fundamental advancement in the field of intracellular therapeutics delivery.

With backing from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital, Entrada Therapeutics is excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The perfect fit:

You are a motivated, resourceful, and enthusiastic biologics-focused Analytical Development Senior Scientist excited to support the company at a critical stage in its growth trajectory. You excel at developing, qualifying, and implementing analytical methods using state-of-the-art instrumentation, including but not limited to HPLC/UPLC, LC-MS, LC-MS/MS, CE and iCE. If you can perform these activities with minimal supervision, yet thrive in a collaborative setting, this role is for you. At Entrada, you will not be siloed, but rather expected to interact across different functional groups, including Discovery, Process Development, Pharmacology, Product Development, and CRO/CMOs. Your ability and desire to thrive in a nimble, fast-paced results-driven environment will set you up for success.

The opportunity:

In this position you will own the analytical developmental needs for the identity, purity, and safety analysis of a variety of different therapeutic modalities, including biologics (antibodies and antibody modalities), peptides, glycans, oligonucleotides and conjugates thereof. This work will support early discovery, process development, and product characterization activities for the evaluation of drug substance, drug product, and stability samples. Ideally, you will be able to perform these analytical method development, optimization, and qualification projects under minimal supervision while leaning on internal and external experts when needed. Furthermore, you will review and evaluate new methodologies/techniques to add to or improve laboratory capabilities and efficiencies. You will be responsible for maintaining laboratory equipment by following appropriate calibration and maintenance activities. You will be a mentor with the potential to manage scientist and research associates in the future. Finally, we hope you enjoy communicating your processes and findings across different formats including authoring and reviewing standard test methods, reports, protocol writing, regulatory filings (IND, IMPD, etc.), patent applications, publications (including review for technical correctness and regulatory compliance) and in internal and external meetings because your work will be critical to the success of the entire company and our ability to treat devastating diseases.

The necessities:

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

Humanity- We genuinely care about patients and about one another

Tenacity- We are relentless and persistent in the pursuit of developing therapies for patients

Creativity- We are creative problem solvers

Collaboration- We are more than the sum of our parts

Curiosity- We have a growth mindset and push conventional thought and theory

To thrive on our team, you will need to come with:

• A Ph.Din Biochemistry, Analytical Chemistry, Molecular Biology or a related discipline with 4-5years of relevant post-graduate biologics method development experience in the Biotech or Pharmaceutical industries (post-graduate academic experience will be considered)
• A strong background in the areas of analytical chemistry/biochemistry, with emphasis on experience and in-depth working knowledge of HPLC/UPLC， LC-MS， LC-MS/MS，CE， iCE and SDS-PAGE is essential
• Specific experience with biologics (therapeutic antibodies, recombinant proteins, etc.) is required, while additional experience with Oligonucleotides is valuable
• Experience with purity (RP-HPLC, SEC-HPLC, AEX/CEX-HPLC), identity (LC-MS high resolution intact mass), aggregates (SEC-HPLC, SEC-MALS), charge variants (AEX/CEX/CIEF/iCIEF), sequencing (LC-MS/MS) techniques is ideal
• Working knowledge of phase appropriate regulatory requirements applicable to analytical development and testing is highly desirable
• Method development experience for both early- and late-stage programs is highly desirable
• Excellent communication (written and verbal) and interpersonal skills
• Works independently with minimal supervision and is highly collaborative with other groups
• Results driven in line with project and team objectives
• Ability to handle multiple high priority tasks in parallel to meet organizational goals

The perks:

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, and you’ll benefit from discretionary time off and an excellent 401K package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

Principal Scientist, Bioinformatics

The organization:

What’s happening at Entrada Therapeutics? Our mission is simple and direct and that is to treat devastating diseases. Using our proprietary Endosomal Escape Vehicle (EEV) platform, we are advancing a diverse pipeline of oligonucleotide, enzyme, protein and peptide programs to efficiently engage intracellular targets across multiple therapeutic areas. We’re a tight-knit team of experts and leaders in both therapeutics development and rare disease spaces -- our novel approach to drug design and delivery addresses several important challenges associated with the development of large and small molecule therapeutics, and represents a fundamental advancement in the field of intracellular therapeutics delivery.

With backing from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital, Entrada Therapeutics is excited to grow and attract colleagues who are ready to join a high energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The perfect fit:

You should be versatile, self-motivated, and looking forward to rolling up your sleeves, as you’ll be involved in all types of data integration and analysis. You should be excited to play a critical role in the development of a bioinformatics and computational platform for oligonucleotide therapeutics discovery. You should enjoy working in a fast-paced environment and collaborating seamlessly across functions with excellent verbal and written skills.

The opportunity:

In this role you will play a critical role in the development of a bioinformatics and computational platform for oligonucleotide therapeutics discovery. You will contribute to the overall scientific strategy for oligonucleotide therapeutics, with a focus on sequence design, data analysis and integration. You should be excited to share your findings across the research teams and serve as the technical and scientific lead.

The necessities:

At Entrada, our passion for science, our devotion to patients and our values drive our behavior:

Humanity- We genuinely care about patients and about one another

Tenacity- We are relentless and persistent in the pursuit of developing therapies for patients

Creativity- We are creative problem solvers

Collaboration- We are more than the sum of our parts

Curiosity- We have a growth mindset and push conventional thought and theory

To thrive on our team, you will need to come with:

• Your PhD in bioinformatics, information sciences, cheminformatics, computational chemistry or a related field will have you ready to perform at your best with at least 6+ years of industry experience in the field of oligonucleotide therapeutics
• You should be an expert in solving scientific problems using program language (python/Perl)
• Your experience using bioinformatics platforms to analyze RNA alternative splicing, RNA secondary structure and pathway analysis should have you ready to succeed in this position
• You should be familiar in therapeutic modalities targeting RNAs (antisense oligo, siRNA, miRNA, gene therapy)
• Having experience in building machine learning/artificial intelligence models based on oligonucleotide data is a great plus, but not a must have for the role
• Would be great if you’ve had experience processing, organizing, analyzing and visualizing complex data and information, such as high throughput genomics and genetics data

The perks:

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, and you’ll benefit from discretionary time off and an excellent 401K package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

Company Overview

Entrada Therapeutics is a biotechnology company dedicated to transforming the treatment of devastating diseases through the intracellular delivery of macromolecules including oligonucleotides and biologics. Entrada’s technology enables the efficient intracellular delivery of proteins, peptides and nucleic acids, thus allowing for the development of programs across several intracellular target classes. The Company’s novel approach addresses current challenges associated with both large and small molecule therapeutics and represents a fundamental advancement in the intracellular delivery of therapeutics.

Entrada is comprised of experts and leaders in both drug development and the rare disease space. In December 2018, Entrada closed a $59 million Series A from 5AM Ventures, MPM Capital, Roche Venture Fund, MRL Ventures Fund and Agent Capital.

Position Summary

Entrada is hiring a highly motivated, collaborative and innovative Drug Metabolism and Pharmacokinetics (DMPK) expert to lead our preclinical DMPK activities in support of the Company’s intracellular oligonucleotide and biologics discovery and development efforts. The successful candidate will report to the Head of Product Development and work with a world-class, multidisciplinary team of drug development scientists and lead the design, analysis and interpretation of preclinical in vitro and in vivo studies. Specifically, the candidate will design, manage and execute in vitro and in vivo programs both in-house and at contract research organizations. The candidate will also be responsible for analyzing, interpreting and modeling DMPK and PK/PD studies. The successful candidate will also have exceptional verbal and written communication skills and will be expected to contribute to scientific publications and regulatory submissions as required.

Job Responsibilities

• Lead all aspects of DMPK design, manage and execute in vitro/in vivo experiments to support preclinical characterization of drug candidates
• Develop and coordinate the execution of studies for measuring drug concentration, target engagement and pharmacodynamic effects in vitro and in vivo
• Lead and coordinate outsourced preclinical studies by interacting closely with CROs
• Partner with the discovery team, toxicology and clinical managers to optimize preclinical models and lead candidates to inform first-in-patient clinical dosing strategies
• Author study reports to support IND filings
• Champion innovation and new initiatives for discovery programs by proactively reviewing literature and other advancements in disease area biology
• Interpret and present research data and findings in internal and external scientific meetings and conferences
• Contribute effectively to patents and scientific publications

Qualifications

Required

• Ph.D. in pharmacology or a relevant scientific discipline
• 6+ years of relevant industrial or academic experience in pharmacokinetics and pharmacology
• Demonstrated knowledge of ADME, PK/PD, toxicokinetics and bioanalytical development of protein therapeutics/biologics/oligonucelotides
• Deep understanding of translational biology
• Significant experience in bioanalytical techniques including assays for assessing serum/tissue drug levels and immunogenicity
• Experience in pre-clinical PK-PD modeling
• Experience with writing technical study reports and supporting IND submissions
• Ability to collaborate in an interdisciplinary team setting spanning discovery to clinical operations and strategy with excellent written and oral communication skills
• Ability to manage multiple high priority activities to support research and company development goals
• Excellent analytical reasoning skills and the ability to effectively troubleshoot and perform root cause analyses

Preferred

• Understanding of in vitro and in vivo toxicology assessment and histopathology
• Experience in assay development for target engagement and biomarker discovery
• Understanding of clinical trial design and PK modeling to support first-in-human clinical studies