Intracellular Therapeutics Pipeline
Diverse and Expanding Pipeline of RNA-, Antibody- and Enzyme-Based Programs Spanning Discovery and Clinical Development
At Entrada Therapeutics, we are driven to transform the lives of patients by establishing a new class of intracellular therapeutics. We are already developing potential treatments across multiple devastating diseases with a simple and scalable EEV platform designed to translate from preclinical to clinical development.
Duchenne Muscular Dystrophy (DMD)
ENTR-601-44 (Exon 44 Skipping Oligonucleotide)
Duchenne Muscular Dystrophy
Discovery
100%
complete
Lead Optimization
100%
complete
IND Enabling
100%
complete
Clinical
22%
complete
ENTR-601-45 (Exon 45 Skipping Oligonucleotide)
Duchenne Muscular Dystrophy
Discovery
100%
complete
Lead Optimization
100%
complete
IND Enabling
100%
complete
Clinical
5%
complete
ENTR-601-50 (Exon 50 Skipping Oligonucleotide)
Duchenne Muscular Dystrophy
Discovery
100%
complete
Lead Optimization
100%
complete
IND Enabling
75%
complete
Clinical
0%
complete
Exon 51 (Exon 51 Skipping Oligonucleotide)
Duchenne Muscular Dystrophy
Discovery
100%
complete
Lead Optimization
100%
complete
IND Enabling
30%
complete
Clinical
0%
complete
Myotonic Dystrophy Type 1 (DM1)
VX-670 (Oligonucleotide) 1
Myotonic Dystrophy Type 1
Discovery
100%
complete
Lead Optimization
100%
complete
IND Enabling
100%
complete
Clinical
40%
complete
Pipeline Expansion
Undisclosed Ocular
Discovery
100%
complete
Lead Optimization
90%
complete
IND Enabling
0%
complete
Clinical
0%
complete
Undisclosed Programs
Discovery
100%
complete
Lead Optimization
55%
complete
IND Enabling
0%
complete
Clinical
0%
complete
Platform Expansion
Discovery
100%
complete
Lead Optimization
0%
complete
IND Enabling
0%
complete
Clinical
0%
complete
References
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1.
In collaboration with
