Engaging Disease-Causing Targets Previously Considered Inaccessible and Undruggable
~75% of disease-causing targets are located inside cells.1 Yet, most are still considered inaccessible.
Only ~1-2% of conventional biological therapeutics reach their intended target.2
Based on preclinical studies, ~HALF of EEV-therapeutics reach their intended target.3
The Challenge with Conventional Intracellular Therapeutics
Delivering a therapy into the cell presents two fundamental challenges:
- Getting it inside the cell.
- Then, most importantly, avoiding the cell’s natural clearing systems so it can reach the intended target.