Become an Entradan

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We exist to help patients and their families live better lives.

Our Values

We love science and our values bind us together to create an environment that is as unique as our research. We are building a company culture where everyone can belong, contribute and grow. Join us.

We connect to and are inspired by our mission to drive innovation and unlock our full potential. We strive for this every day and in every role, so that each Entradan can grow and fully contribute to our community.

Entrada takes care of you so you can focus on our science and mission; our perks and benefits are designed to meet your needs regardless of what season of life you are in. We celebrate the big and the small and rally around our collective ability to make a difference in the lives of patients and their families.

Humanity

We genuinely care about patients and about one another.
Tenacity

We're relentless and persistent in the pursuit of developing therapies for patients.
Creativity

We're creative problem solvers.
Collaboration

We're more than the sum of our parts.
Curiosity

We've got a growth mindset.

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Listen as Dipal Doshi, our CEO, shares more about our mission, the culture we’re building and how we’re working together to develop new therapies to treat devastating diseases.

Meet Our Entradans

BK Choi, PhD

Senior Principal Scientist, Product Development
Murali Mallem

VP and Head of CMC
Kimberli Kamer, PhD

Senior Scientist, Pharmacology
Nanjun Liu

Associate Director, Bioanalytical Lead
Nick Long, PhD

Senior Scientist, Antibody and Protein Engineering
Sara Blake

Research Associate II, Neuromuscular and Cardiac Biology
Nelsa Estrella, PhD

Associate Director, Neuromuscular Therapeutics
Leo Qian, PhD

Co-founder & VP, Discovery Research

What Sets Us Apart:

Since our inception, we have worked to build a high-performing, inclusive and diverse team, which is a core element of our culture. Entradans are committed to making a difference in the lives of patients, their families and care partners. We believe that by embracing differences, we have a unique advantage in challenging the status quo to apply innovative thinking to long-existing medical challenges.

56% Identify as women
52% Asian, Hispanic, Latino, Black, or African American
62% Of our Senior Leadership Team and Board is made up of women and minorities

Self-reported, as of March 2024.

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Our Comprehensive Benefits:

Wellness

We offer a $500 wellness benefit to support you and your individual priorities.
Fuel

Subsidized lunches, snacks, cold brew, drinks and treats.
Commuter Benefits

We offer $300 to cover your commute, however you do it.
Connections

Organized coffee dates, company-wide activities and gatherings.
Development & Learning

We offer individual and broad approaches to growth.
Mobile Stipend

We help you stay connected by offsetting your data plan.
Swag

We always offer opportunities to show your love for Entrada.
Parental Leave

We give you time to connect and bond with your new child.
Milestones

Personal or professional, we celebrate the big and small stuff.

Excited by what you see? Check out our Current Openings and Benefits and apply to join the Entrada team!

Learn About Our Benefits

Current Openings

Check out our current openings below.

Senior Research Associate, Translational Sciences (in vitro)

Boston, MA

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Director, Quality GCP & GLP

Boston, MA

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Vice President/ Senior Vice President, Clinical Development

Boston, MA

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Research Associate II, in vivo Pharmacology (CONTRACT)

Boston, MA

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Research Associate II, in vitro Pharmacology (CONTRACT)

Boston, MA

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Senior Specialist, Quality GMP (CONTRACT)

Boston, MA

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Senior Research Associate, Ocular Research

Boston, MA

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Senior Scientist II, Bioanalytical

Boston, MA

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Associate Director, Drug Product Development & Manufacturing

Boston, MA

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Clinical Trial Manager

Boston, MA

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Research Associate I, Downstream CMC (CONTRACT)

Boston, MA

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There's more to explore

Boston, MA

The Organization

What's happening at Entrada Therapeutics? Entrada is a clinical-stage biopharmaceutical company aiming to transform the lives of patients by establishing a new class of medicines that engage intracellular targets that have long been considered inaccessible.

Our Endosomal Escape Vehicle (EEV™)-therapeutics are designed to enable the efficient intracellular delivery of a wide range of therapeutics into a variety of organs and tissues, resulting in an improved therapeutic index. Through this proprietary, versatile and modular approach, Entrada is advancing a robust development portfolio of RNA-, antibody- and enzyme-based programs for the potential treatment of neuromuscular, ocular, metabolic and immunological diseases, among others.

Our lead oligonucleotide programs are in development for the potential treatment of people living with Duchenne who are exon 44, 45 and 50 skipping amenable. We have also partnered to develop a clinical-stage program, VX-670, for myotonic dystrophy type 1.

We are a tight-knit team of experts and leaders in both therapeutic development and rare diseases and are excited to grow and attract colleagues who are ready to join a high-energy, dedicated team that likes to get things done and dramatically improve the lives of patients and their families.

The Perfect Addition to Our Team

You are self-motivated, highly collaborative, and eager to roll up your sleeves, as you will contribute to several aspects of our translational biology group. Your background should be in biology or biomedical engineering, with experience in cell biology, in vitro 2D and 3D disease models, and molecular biology. You will work alongside team members to help characterize and validate innovative medicines to treat some of the most challenging diseases.

The Opportunity

The Senior Research Associate will have the opportunity to work with disease models and cell-based assays, such as ddPCR, ELISA, LabChip, and confocal microscopy. They will support pre-IND and IND-enabling studies using in vitro cell systems. The ideal candidate will be managing and ordering chemicals and supplies, as well as preparing procedures and other reports. There will also be opportunities to present data and research findings at internal meetings.

Responsibilities

Maintain and culture the in vitro 2D and 3D cell models to support the in vitro preclinical studies.
Conduct experiments to critically assess in vitro assays (e.g. DNA/RNA/protein extraction, RT-PCR, RT-qPCR, ddPCR, western blot, ELISA, immunostaining, imaging, etc.) and data analysis.
Collaborate with Neuromuscular, Ocular, and Biologics groups for method transfer and to acquire materials for subsequent cell-based assay development and testing.
Ensure reagents for in vitro assay experiments are well stocked and keep a detailed record of all experiments in a digital lab notebook.
Present updates regularly in the translational group meetings.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

Humanity - We genuinely care about patients and about one another.
Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
Creativity - We are creative problem solvers.
Collaboration - We are more than the sum of our parts.
Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

BS in biology, biomedical engineering, or a related field with 4+ years of industry experience (or a MS in related field with 2+ years’ experience).
Strong communication and organizational skills.
Hands-on experience with in vitro assays including PCR, ddPCR, qPCR, Western blotting, and immunostaining.
Hands-on experience with muscle cells, organoid systems, and/or engineered tissues is a plus.
The ability to critically assess experimental results, troubleshoot, and come up with creative and effective solutions.
The drive to have a more complete understanding of project goals to effectively manage your time and prioritize experiments.

The Perks

By becoming a team member here at Entrada, you’ll have access to competitive health, dental, and vision coverage, as well as life insurance, and short term and long-term disability insurance. We value work life balance, you'll benefit from discretionary time off, paternity leave, and an excellent 401(k) package. We also offer a generous transportation stipend to commute as you wish. Our location in the vibrant and growing Seaport District is close to all the best that the city of Boston has to offer.

Entrada Therapeutics is an equal opportunity employer. Qualified candidates will receive consideration for employment without regard to race, color, religion, national origin, gender, sexual orientation, gender identity or expression, age, mental or physical disability, and genetic information, marital status, citizenship status, military status, protected veteran status or any other category protected by law.

Third Party Staffing Agencies

Entrada does not accept unsolicited resumes from any source other than directly from candidates. For the protection of all parties involved in the recruiting process, resumes will only be accepted from recruiters/agencies if a signed agreement is in place at the inception of the recruiting effort and authorized for a specified position. Unsolicited resumes sent to Entrada from recruiters/agencies do not constitute any type of relationship between the recruiter/agency and Entrada and do not obligate Entrada to pay fees if we hire from those resumes.

Privacy Statement

Entrada Therapeutics, Inc. (the “Entrada,” “we,” “us,” or “our”) respects your privacy and we want you to be familiar with how we collect, use, share, or otherwise process, your Personal Information. Please reference our privacy statement here to understand how and when your data is being used.

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Boston, MA

The Organization

The Perfect Addition to Our Team

You are driven and enthusiastic. You thrive in a fast-paced collaborative environment and can manage multiple projects concurrently. You are detail-oriented and able to review and analyze quality issues quickly in order to provide robust and timely solutions.

You are dependable and accountable for your work. You are able to lead teams and develop strategies while not being afraid to roll up your sleeves and review clinical trial-specific documents and GLP reports.

You are an excellent team player and relationship builder. You know when to step in and lead something and when to offer your support. You excel at building relationships and trust with your key stakeholders.

The Opportunity

Entrada is seeking a Director, GCP/GLP Quality to manage GCP and GLP quality assurance activities. This role will ensure quality and compliance of Entrada’s development programs with respect to clinical and nonclinical studies. This position reports into the Vice President of QA.

Responsibilities

Act as GCP subject matter expert within the QA function to enhance the Quality System in accordance with ICH Guideline E6 (R2) Good Clinical Practice (GCPs), 21 CFR part 58 Good Laboratory Practices (GLP), and other global regulatory authority requirements and industry practices.
Identify controlled document improvements, creation, and training needs.
Collaborate and provide QA expertise on investigations, corrective and preventive action (CAPA) plans, trial protocol deviations, complaints, risk management, risk assessments, recalls, safety events/reporting, relevant regulatory submission sections, and trial documentation review.
Represent QA on clinical study teams and conduct QA review of clinical study protocols, study plans and protocol deviations.
Design and execute risk-based audit plans/schedules in collaboration with clinical and nonclinical study teams, including establishment of appropriate quality compliance criteria to assure compliance with regulations, guidelines, and standards.
Lead qualification, routine and for-cause audits of Clinical Research Organizations (CRO), investigator sites, laboratory and data management vendors as well as other clinical vendors to assess effectiveness of their QMS and compliance to approved clinical study protocols and contracts.
Conduct internal audits to assess effectiveness of Entrada’s GCP/GLP QMS and process compliance including Clinical Study Report (CSR).
Timely issuance of audit plans, reports, observations, and oversee audit response processes to drive audits to closure.
Evaluate audit observation trends and compliance risks and escalate to QA Management, as required.
Ensure the clinical and nonclinical sites are audit ready and compliant at all times.
Participate (eg, host/co-host inspections, lead or support inspection back-room/preparation room activities) during external and regulatory agency inspections.
Develop and report on key quality metrics, periodic quality reports, and audits as needed.
Ensure timely collaboration with Entrada staff to ensure any non-compliance is elevated appropriately and addressed in a timely manner.
Work cross-functionally to solve problems and produce solutions that work for the broader team.
Work across all levels in the organization to deliver GCP/GLP Quality compliance.
Partner with external collaborators, contractors, and contract research organizations to fully support drug development activities.
Lead continuous improvement initiatives.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

Humanity - We genuinely care about patients and about one another.
Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
Creativity - We are creative problem solvers.
Collaboration - We are more than the sum of our parts.
Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

Scientific degree required; advanced degree preferred with 10+ years of relevant GCP experience in the biotechnology industry.
Prior regulatory inspection experience required (eg, hosting inspections, inspection readiness planning and execution, etc.)
Strong knowledge of GCP, GCLP, GLP, GVP, and ICH clinical requirements.
Prior experience with clinical and nonclinical studies and CRO oversight.
Experience working on US and international phase 1 and 2 clinical studies.
Real-time working knowledge of Quality Assurance methodologies.
Strong organizational skills and ability to work independently.
Strong verbal and written communication skills.
Strong ability to create practical and efficient processes.
Ability to travel 20% of the time, as dictated by the schedules of mandatory events and medical meetings.

The Perks

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Boston, MA

The Organization

Responsibilities

Provide oversight and leadership of clinical programs including strategic planning, execution, and completion of clinical trials according to all applicable regulations and guidance, ICH/GCP, and Entrada SOPs.
Support growth and management of Clinical Development function, including oversight of clinical leads, biostatistics, clinical pharmacology and biomarkers.
Partner with Clinical Operations to ensure all clinical study activities are completed in accordance with applicable regulations and guidance; ICH/GCP, and Entrada SOPs.
Review clinical data from all phases of development and assist in generating study reports and publications.
Serve as study medical monitor, as needed.
Develop and maintain relationships and serve as the main medical liaison with key opinion leaders and Principal Investigators.
Represent Entrada’s clinical team in interactions with regulatory agencies.
Provide management personnel with timely updates on progress and changes in scope, schedule, and resources as required.
Ensure compliance with all applicable regulatory standards related to global clinical trials and interactions with physicians.
Collaborate closely with internal research team to integrate translational research into development and clinical strategies, and regulatory submissions.
Responsible for the clinical content of all clinical and regulatory documents, including protocols, INDs, CTAs, investigator brochures, CRF’s, annual IND reports, CSR’s, ISS’s, ISE’s, and clinical expert reports.
Organize and present at relevant clinical advisory boards, data monitor committees and medical/scientific meetings.
Travel nationally and internationally, as needed.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

Humanity - We genuinely care about patients and about one another.
Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
Creativity - We are creative problem solvers.
Collaboration - We are more than the sum of our parts.
Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

MD or DO (physician) required, preferences for formal training in neuromuscular disease.
10+ years of industry experience.
Experience with clinical development in Neurology/Neuromuscular disorders.
Strong scientific background.
Strong project planning, leadership, negotiation and presentation skills as well as an ability to contribute creative yet practical solutions to problems.
Experience with all aspects of management of clinical trials from inception to completion across all phases of development including study design.
Experience in communicating/presenting key/complex information to department/functional lead(s)/senior management.
Strong knowledge of FDA and ICH regulations.
Expert knowledge of Good Clinical Practice (CGP).
Ability to multi-task and manage several projects in parallel, paying attention to detail.
Ability to forge cross-functional working relationships with internal teams and external project partners.
Ability to be proactive in identifying issues and hurdles that may hinder the effective implementation of the trial and resolve the issues in a timely fashion.

The Perks

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Boston, MA

The Organization

The Perfect Addition to Our Team

The in vivo Pharmacology contractor will primarily be focused on contributing to the execution of in vivo experiments, directly fulfilling company goals, and validating our modular intracellular delivery platform. This position will create exposure to in vivo techniques and animal models, ex vivo assays, as well as the opportunity to participate in cutting edge science.

This position offers a long-term contract opportunity with Entrada. The individual will be based on-site 5 days per week in our Seaport office.

The Opportunity

Entrada is hiring a highly motivated in vivo Pharmacology contractor to support the Company’s intracellular oligonucleotide targeted delivery and biologics discovery and development efforts. The successful candidate will work closely with a highly engaged, talented in vivo scientist including In vitro Pharmacology team members. The successful candidate is expected to be involved in all aspects of early concept/Discovery pre-clinical in vivo studies including dosing, perfusion, tissue collection and cryo-pulverization of tissue samples. Furthermore, the successful applicant will be working under the supervision of in vivo team members for execution and completion of pre-clinical PoC studies upon completion of training period. As part of the Pharmacology functional team, this role could contribute broadly to the mission of advancing validated targets into the drug discovery portfolio pipeline.

Responsibilities

Perform various in vivo routes of administration in rodents specifically proficient in tail vein intravenous dosing, including but not limited to, subcutaneous, intraperitoneal, intramuscular, and intranasal.
With training and supervision, carry out all workflow process of in vivo pharmacology to support studies, including animal handling, dosing, bleeding, necropsy, tissue collection and wet lab sample processing.
Perform in vivo tumor efficacy studies including subcutaneous and disseminated tumor cell implantation and longitudinal tumor volume measurement.
Perform rodent dissection and tissue microdissection.
Perform basic animal handling and restraint following animal welfare rules and regulations.
Assess and monitor rodent health.
Collect and document important in-life data points from rodents.
Participate in the processing and analysis of various tissue types across multiple rodent species.
Support and participate in basic ex vivo assays.
Perform aseptic cell culture and primary cell isolation and maintenance.
Demonstrate a high level of initiative to troubleshoot and accurately perform data analysis and present experimental data to internal groups.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

Humanity - We genuinely care about patients and about one another.
Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
Creativity - We are creative problem solvers.
Collaboration - We are more than the sum of our parts.
Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

BS or MS with 2 + years of relevant experience in areas related to Cell Biology, Molecular Biology and/or Pharmacology in an industrial/CRO or academic setting.
Experience working with rodents, administering doses through various methods including but not limited to PO, IP, IV, SC and IM, and conducting post-study processes including blood draws, necropsies, and ex vivo sample analysis.
Excellent organization and planning skills, the ability to work in a demanding environment independently or as part of a team, strong motivation with a dedicated work ethic.
Experience with Contract Research Organizations (CROs) is an asset.
Experience running flow, ICC, FISH, and/or IHC imaging assays is a plus.
Prior multicolor flow cytometry, ELISA or other methods of cytokine/analyte analysis preferable but not mandatory.
Hands-on experience with a range of in vitro/ ex vivo techniques (such as RNA/DNA extraction, RT-qPCR, ELISA, protein analysis via Western blot, WES, and/or MSD) is desirable.
A passion for contributing to a team-oriented, diverse, and inclusive work environment.
Excellent multitasking abilities to thrive in a fast-paced, collaborative setting.
Prior experience or knowledge of cancer biology, immunology and understanding of in vivo models used in immuno-oncology preferable but not mandatory.
Software knowledge: Windows, MS Office (Outlook, Word, Excel), GraphPad Prism, FlowJo, Benchling.
Strong attention to detail and ability to follow protocols and lab procedures.
Strong written and verbal communication skills and ability to work effectively, independently, and collaboratively in a fast-paced multidisciplinary team environment.#LI-JF1

The Perks

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Boston, MA

The Organization

The Perfect Addition to Our Team

You should be versatile, self-motivated, and looking forward to rolling up your sleeves, as you will be involved in all aspects of our pharmacology studies. You have a team player mentality and excellent communication skills that will allow you to collaborate effectively as you work alongside your team as well across-functionally within the organization.

The Opportunity

The in vitro Pharmacology contractor will primarily be focused on contributing to the execution of in vitro experiments, directly fulfilling company goals, and validating our modular intracellular delivery platform.

This position offers a long-term contract opportunity with Entrada. The individual will be based on-site 5 days per week in our Seaport office.

Responsibilities

Contribute broadly to advancing validated targets into the drug discovery pipeline.
Responsible for carrying out in vitro preclinical studies to advance programs including target nomination, analysis, and building scientific rationales for disease selection.
Evaluate, validate, and develop disease models to investigate the efficacy of EEV-mediated delivery including in vitro techniques to drive go/no-go decisions.
Regularly collaborate across teams and with the Discovery Group to demonstrate mechanistic proof-of-concept and contribute to selecting novel therapeutic modalities that include oligonucleotides, peptides, and antibodies.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

Humanity - We genuinely care about patients and about one another.
Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
Creativity - We are creative problem solvers.
Collaboration - We are more than the sum of our parts.
Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

Bachelors with 2 – 4 years or Masters degree with experience performing in vitro cell culture and biochemical assays within academia and/or the pharmaceutical/biotech industry.
Experience with in vitro laboratory techniques such as PCR, gel electrophoresis, Western blots, RNA and protein extraction, qPCR, ELISA, mammalian cell (tissue) culture, transfection, and lentiviral related work experience.
Experience with cellular readouts such as luminescence, cell viability, fluorescence, ELISA, flow cytometry, high content imaging, etc. is ideal.
Be able to solve routine operation and scientific problems requiring deductive reasoning.
Good working knowledge of Microsoft suite of Software (Word, Excel, PowerPoint).
Excellent verbal and written communication skills
Strong communication skills and ability to work effectively across cross functional teams.
“Hands-on” mentality in moving projects forward
Desire to work in an innovative and collaborative environment pursuing high reward science.

The Perks

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Boston, MA

The Organization

The Perfect Addition to Our Team

You are analytical and detail oriented. You thrive in a fast-paced collaborative environment and can manage multiple projects concurrently. You are detail-oriented and able to review and analyze quality issues quickly in order to provide robust and timely solutions. You are dependable and accountable for your work. You are an excellent team player and relationship builder.

The Opportunity

The Sr. QA Specialist will be responsible for supporting GMP QA processes, including master and executed batch record review and disposition of drug substances and drug products (including package and labeling). The positions is also responsible for owning and supporting deviations, change control, and CAPA‘s. This role will contribute to development of the internal Quality Management System (QMS) and support other internal QA functions including training, documentatio0n, This role is based in Boston, MA and reports directly to the Director of GMP QA.

Responsibilities

Review and approve Master and Executed Batch Records.
Review in-process, release, and stability data.
Disposition lots from intermediates through finished drug product.
Supports internal and external deviations, change control, and CAPA.
Supports Vendor Management Program, including management of vendor audit activities and the Approved Supplier List.
Writes and implements changes to Standard Operating Procedures.
Coordinates and reviews change control activities to drive change control records to closure.
Delivers expertise and guidance to drive continuous improvement of standardized processes for managing GxP documents/records.
Performs the appropriate QA review/approval of SOPs, SOP-related documents, and Policies.
Leads and supports understanding and adoption of risk-based approaches and decision making.
Serve as Quality resource, representing QA on teams in support of assignments.
Interacts on cross-functional teams including manufacturing and QC.
Supports all GxP functions as needed.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

Humanity - We genuinely care about patients and about one another.
Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
Creativity - We are creative problem solvers.
Collaboration - We are more than the sum of our parts.
Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

5+ years of experience in chemistry, biology, or related scientific or engineering field.
Experience supporting GMP and CMC functions from QA perspective is required.
Strong attention to detail and ability to communicate and collaborate with stakeholders outside of Quality.
Authoring and reviewing SOP’s.
Based in the Boston area with ability to come into the office 3 days.
Method validation, stability, and other QC support functions are nice to have. #LI-DS1

The Perks

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Boston, MA

The Organization

The Perfect Addition to Our Team

You are a versatile, self-motivated, and eager Senior Research Associate who is looking forward to rolling up your sleeves and contributing to all aspects of the ocular pipeline here at Entrada. You look forward to supporting efforts for testing EEV, antisense oligonucleotides, small interfering ribonucleic acids, and gene editing in vivo and in vitro. You are ready to partner with drug discovery scientists as we evaluate gene targeting modalities and carry out analytical assays for functional validation both in vitro and in vivo.

The Opportunity

The Senior Research Associate, Ocular will have the opportunity to be involved in several aspects of discovery biology work, including assisting with and performing ocular injections in vivo, tissue collection and processing, and analysis of samples from in vivo, ex vivo and in vitro studies. They will be an integral part of the Ocular team, supporting the development and expansion of Entrada’s Ocular portfolio.

Responsibilities

• Perform techniques like DNA/RNA/protein extraction, RT-PCR, RT-qPCR, ddPCR, western blot, tissue embedding, sectioning, immunostaining, and imaging.
• Maintain and culture cell lines in support to in vitro and ex vivo studies
• Develop and execute cell-based or ex-vivo assays for validating biological activity of oligonucleotide therapeutics.
• Prepare SOPs and other reports and publications.
• Collaborate with cross functional Discovery Teams to advance the pipeline and contribute to the completion of corporate goals.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

Humanity - We genuinely care about patients and about one another.
Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
Creativity - We are creative problem solvers.
Collaboration - We are more than the sum of our parts.
Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

• BS with 4+ years or MS with 2+ years of relevant experience.
• Experience with handling rodents and perform tissue collection for in vivo studies.
• Experience in the ocular space, including ocular injection, is strongly preferred.
• Hands-on experience with in vitro assays including PCR, ddPCR, qPCR, Western blotting, and immunostaining.
• Organized and focused on moving projects forward.
• Desire to work in an innovative and collaborative environment pursuing high reward science.
• Ability to juggle and prioritize multiple responsibilities, projects, and timelines. #LI-DS1

The Perks

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Boston, MA

The Organization

The Perfect Addition to Our Team

As a member of the Bioanalytical group in the Product Development Team, you are versatile, self-motivated, timeline- and process-oriented, and look forward to rolling up your sleeves and diving into details, and overcoming obstacles. You will be responsible for mentoring members of the team and be accountable for their day-to-day operations and personal career development. You will successfully lead and coordinate bioanalytical support functions across various modalities, including oligonucleotide and biologics modalities, to perform both qualitative and quantitative bioanalysis in complex biological matrices. To accomplish these aims you will actively explore, investigate, and implement innovative technologies to meet program timelines. You will lead internal efforts to provide timely bioanalytical support for discovery projects and pre-IND clinical candidate studies. Additionally, you will be a key contributor to documents supporting regulatory filings and will have the opportunity to contribute to scientific publications.

You also enjoy a fast-paced environment and juggling competing priorities. You have excellent verbal and written communication skills, you follow up and follow through, bringing solutions to problems efficiently. You work successfully in a team environment with strong interpersonal skills to effectively build working relationships inside and outside the company.

The Opportunity

Work within the Bioanalytical Team to enable the full spectrum of EEV-conjugated modalities development from early discovery candidate selection through late-stage process development.

Responsibilities

Develop, qualify, and implement bioanalytical assays using LC-MS/MS and ligand binding assay (LBA) to support PK and biodistribution studies for therapeutic candidates including oligonucleotides, biologics, and peptides.
Perform both qualitative and quantitative bioanalysis in various biological matrices (plasma, CSF, urine, and tissues, etc.) across different species. Generate high-quality data and reports in a timely manner to meet project deliverables.
Oversee bioanalytical deliverables supporting discovery project activities, candidate enabling studies, and clinical candidate IND enabling studies; provide scientific guidance and technical support on method development, qualification, and sample analysis in-house as well as at CROs.
Support the implementation of new and upcoming technologies/platforms both within and outside the field of expertise to meet challenging program needs.
Mentor and train team members and colleagues on scientific concepts and technical details regarding various bioanalytical approaches.
Lead troubleshooting efforts for bioanalytical assays; Proactively identify and solve technical challenges/bottlenecks to maintain/improve assay robustness and efficiency.
Implement processes to ensure timelines are met with data integrity; communicate and interface with stakeholders including discovery, preclinical, CMC, and external CROs to define and deliver strategies in a flexible manner to support project timelines across multiple programs.
Interpret and present bioanalytical data internally as well as in cross-functional team meetings; serve as an SME on behalf of the bioanalytical team for technical, strategic, and prioritization discussions to advance program objectives.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

Humanity - We genuinely care about patients and about one another.
Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
Creativity - We are creative problem solvers.
Collaboration - We are more than the sum of our parts.
Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

A PhD in chemistry, biochemistry, pharmacology, analytical chemistry, or a related field with at least 5 years of bioanalytical sciences; and an equivalent combination of education and experience (e.g. MS degree with at least 8 years experience) will be considered.
Demonstrated leadership acumen and strong project management/organizational skills; Proven track record of fostering a collaborative work environment.
Subject matter expert with extensive hands-on experience with developing, qualifying, implementing, and troubleshooting LC-MS/MS and ligand binding-based assays to support a variety of therapeutic modalities including oligonucleotides, biologics, and peptides.
Ability to work independently in a fast-paced, competing priority environment, as well as in a cross-collaborative team setting. Excellent communication skills (oral and written) and a track record of cross-disciplinary collaboration are essential.
Knowledge/experience of pharmacokinetics, drug metabolism, immunogenicity, and biomarker studies are highly desirable.
Experience with ligand binding assays such as ELISA and MSD is preferred.
Knowledge and experience with assay development, transfer, qualification, and validation to external CROs in a GLP/GxP environment is considered a plus.

The Perks

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Boston, MA

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The Perfect Addition to Our Team

You are a motivated, resourceful, and enthusiastic Drug Product Development & Manufacturing individual who is excited to support the company at a critical stage in its growth trajectory. You excel at formulation & drug product development (liquid and lyophilized), GMP manufacturing of drug products. If you can lead these activities with minimal supervision, yet thrive in a collaborative setting, this role is for you. At Entrada, you will not be siloed, but rather expected to interact across different functional groups, including Discovery, Process Chemistry, DS Development & Manufacturing, Analytical Development & Quality Control, Product Development, Clinical Operations, and CRO/CDMOs. Your ability and desire to thrive in a nimble, fast-paced results-driven environment will set you up for success.

The Opportunity

Lead the drug product development and manufacturing activities for Entrada’s novel pipeline programs. You will report to the Sr. Director of Drug Product Development & Manufacturing and will focus on developing liquid, lyophilized formulations, process development, and manufacturing activities for Oligopeptide and Biologics Drug Products.

Responsibilities

Lead drug product formulation, characterization, process development, technology transfer, scale-up, and manufacturing activities for early to late-stage pipeline programs.
Develop lyophilization cycles & processes to increase the stability of drug products.
Focus on routes of degradation of drug products in liquid and lyophilized formulations under accelerated temperature, refrigerated storage conditions, and under different stresses in a variety of containers.
Serve as a subject matter expert and provide direct oversight for drug product manufacturing activities at CDMOs including formulation, aseptic filling, visual inspection, manufacturing investigations, and change controls.
Lead and manage the execution of various drug product-related studies including formulation robustness, filter validation, CCIT, extractables and leachable, in-use material compatibility, and shipping.
Facilitate timely execution, disposition, and release of drug product batches through detailed technical review of master batch records, executed batch records, and other cGMP documentation.
Support packaging & labeling activities of bulk drug products (if needed)
Collaborate with QC stability lead in the design of phase-appropriate stability studies as per ICH guidelines.
Responsible for driving execution of current production plan at CDMOs with long-term vision.
Lead issue resolution, escalating appropriately to internal and/or joint governance if required.
Develop, author, review, and approve technical study protocols, reports, and documentation related to manufacturing including quality documents.
Autor/review change controls to introduce process improvements through the lifecycle of programs from Phase 1 through Phase 3/validation and commercialization.
Author/review related sections in regulatory filing documents (IND, IMPD, NDA, etc.).
Partner with Entrada team for CDMO due diligence during new CDMO selection to vet capabilities, risks, and investments required.
Serve as drug product SME to support CMC and program teams in technical due diligence, CRO and CMO capability assessment, selection, and management for formulation and drug product development and manufacture.
Provide input and participate in long-term strategic initiatives which enable sufficient growth to meet the program’s needs.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

Humanity - We genuinely care about patients and about one another.
Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
Creativity - We are creative problem solvers.
Collaboration - We are more than the sum of our parts.
Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

Requires an advanced degree in a scientific or engineering discipline with 10+ years of related experience in the pharmaceutical industry.
Demonstrated technical expertise in drug product manufacturing and development including formulation, process characterization (by QbD), tech transfer, scale-up, and clinical and commercial manufacturing.
Experience with aseptic filling of liquid vials, pre-filled syringes, and lyophilized drug product vials.
Significant experience in managing/collaborating with CRO, CMO, drug product primary packaging component suppliers, and production partners.
Demonstrated ability to develop and maintain program timelines and budgets
Working knowledge of industry practices and regulations (e.g. GxP, ISO, ICH, etc.) across multiple health authorities (e.g. FDA and EMA). Ability to interpret and relate Quality standards for implementation and review.
Ability to lead and ensure successful execution of DP development activities, including but not limited to formulation development/stability studies, in-use stability studies, extractable and leachable assessments, process development (scale-up) studies, and sterilizing filter sizing.
Strong project management, interpersonal, communication, negotiation, and problem-solving skills preferable.
Strong ability to communicate clearly and professionally both in writing and verbally.
Ability to travel up to 20% (domestic and international). #LI-DS1

The Perks

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Boston, MA

The Organization

The Perfect Addition to Our Team

You are excited about the opportunity to spearhead clinical trial activities and support the build of our clinical operation function here at Entrada. You are well organized and like to share best practices in clinical operations. You enjoy a fast-paced environment and juggling competing priorities and are willing to jump in and help wherever it is needed. You follow up and follow through, efficiently connecting problems with solutions. You work successfully in a team environment and have strong interpersonal skills, in order to effectively build working relationships inside and outside of the company.

The Opportunity

This individual will lead in the day-to-day operations, planning, set-up, execution, and closeout of assigned clinical trials. They will oversee the planning and management of the operational aspects, including CRO and vendor oversight, to achieve project milestones and clinical study timelines in alignment with company goals and in compliance with local, ICH, GCP, and company policies and procedures.

Responsibilities

Ownership of all operational aspects of clinical trials, including CRO and vendor management.
Lead and/or support study activities, including vendor evaluation and selection, country and site selection, informed consent development and maintenance, eCRF design and implementation, protocols, study plans and manuals, IBs, CSRs
Proactively identify and support resolution/escalation of trial conduct-related issues.
Manage and lead cross-functional trial teams, including collaborating with internal team members and external vendors for the planning and execution of clinical trials, through closeout.
Provide regular up-to-date trial information and regular updates on trial progress/performance to internal stakeholders (enrollment, eligibility, protocol deviations, AE reporting etc.).
Oversee clinical monitoring from site qualification to site closure visits to assure integrity of clinical data with respect to accuracy, accountability and documentation through review of case report forms, source documents, and medical records.
Oversee the review/cleaning and reconciliation of all clinical data, including EDC, PROs, and 3^rd party labs to support timely database lock and the accurate analysis of clinical data.
Partner with relevant stakeholders to develop and implement appropriate study-specific training to all relevant study-related personnel (internal, CRO, Site staff, and other relevant 3^rd parties).
Support development of department documentation, such as SOPs.
Help develop, organize, and maintain study budgets, working with business operations to ensure accurate forecasting.
Support monitoring activities and visit clinical study sites as needed.

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

Humanity - We genuinely care about patients and about one another.
Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
Creativity - We are creative problem solvers.
Collaboration - We are more than the sum of our parts.
Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

BA/BS degree with 5 + years direct experience overseeing clinical trial activities.
Strong knowledge of ICH/GCP and regulatory requirements.
Deep experience in the drug development process, including trial design, trial planning and management, and CRO and vendor oversight.
Excellent verbal and written communication skills.
Proven ability to work effectively across functions.
Expected travel up to 20%. #LI-JF1

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Boston, MA

The Organization

The Perfect Addition to Our Team

You are a versatile, self-motivated professional who enjoys rolling your sleeves to contribute to the overarching goals. You enjoy a fast-paced, highly dynamic environment where you learn and grow in the role. You follow up and follow through, connecting problems with solutions efficiently. You are a good communicator and enjoy collaborating with internal and external stakeholders.

The Opportunity

The Research Associate I, Downstream CMC (Contract) position will support the Company’s intracellular biologics discovery programs. They will work closely with downstream and upstream teams to progress discovery and development programs. The successful candidate will execute the purification of recombinant proteins using AKTA Avant, Protein Maker and Bio-Rad NGC systems. By the end of the contract, the candidate will gain hands-on laboratory experience and a solid practical understanding of downstream operations involved in producing recombinant proteins.

Responsibilities

Prepare buffers for downstream (homogenization, solubilization, and protein purification) operations.
Operate AKTA Avant, Bio-Rad NGC, purifier, and TFF systems for protein purification.
Execute homogenization, solubilization, and refolding of inclusion bodies.
Clean-in-place AKTA and Bio-Rad systems after use.
Run SDS-PAGE gels, western blots, and endotoxin assays.
Input experimental details and observations in the laboratory notebooks.
Present data and research findings in internal team meetings.
Strong communication skills (oral and written) and ability to work effectively across functions.
Maintain inventory of reagents and consumables (as needed).
Prepare media and feed for shake flasks and fermenters (as needed).
Set up, inoculate, and operate shake flasks and lab-scale fermenters (as needed).
Sample shake flask and fermenter to monitor culture growth, metabolite levels, and protein production (as needed).
Run activity, SEC-HPLC and Ion exchange HPLC assays (as needed).

The Necessities

At Entrada, our passion for science, our devotion to patients and our values drives our behavior:

Humanity - We genuinely care about patients and about one another.
Tenacity - We are relentless and persistent in the pursuit of developing therapies for patients.
Creativity - We are creative problem solvers.
Collaboration - We are more than the sum of our parts.
Curiosity - We have a growth mindset and push conventional thought and theory.

To thrive on our team, you will need to come with:

BS or MS degree in biochemistry, biochemical engineering, biotechnology, or a related field with prior experience in R&D laboratory.
Experience with AKTA or Bio-Rad systems for purification of recombinant proteins using multimodal chromatography, Ion exchange, and other types of chromatography.
Experience with TFF operation to concentrate and diafilter recombinant proteins (a plus).
Experience in a fast-growing, dynamic organization; preferably small biotech is preferred.
Experience in handling high throughput instruments such as protein maker is preferred.
Knowledge and use of molecular biology and protein biochemistry techniques.
Able to work outside of regular business hours and weekends.
Growth mindset with ability to adapt to changing priorities.
Strong communication skills (oral and written) and ability to work effectively across functions.
Desire to work in an innovative and collaborative environment pursuing high-reward science.

The Perks

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